ArticleThe Pediatric infectious disease journal2017
Roles of Medication Responsibility, Executive and Adaptive Functioning in Adherence for Children and Adolescents With Perinatally Acquired HIV.
Article in The Pediatric infectious disease journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01418014 (Adolescent Master Protocol), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Master Protocol
Who cites it
13 citing papers in PubMed.
- Cannabis Effects on Neurocognition and HIV-Related Outcomes: Protocol for a Longitudinal Observational Cohort Study.JMIR research protocols · 2026Article
- Executive Function and Adherence in Children and Adolescents Living With HIV: Evidence From the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study.Journal of child neurology · 2026Article
- AI applications in HIV research: advances and future directions.Frontiers in microbiology · 2025Review
- Mixed Methods Evaluation of a Youth-Friendly Clinic for Young People Living with HIV Transitioning from Pediatric Care.Tropical medicine and infectious disease · 2024Article
- Factors Impacting the Treatment Readiness of Youth Starting Antiretroviral Treatment in the United States.AIDS patient care and STDs · 2024Article
- Central Nervous System Complications of HIV in Children.Current HIV/AIDS reports · 2024Review
- "I can live a normal life": Exploring adherence to antiretroviral therapy in Indonesian adolescents living with HIV.Belitung nursing journal · 2022Article
- Machine-learning classification of neurocognitive performance in children with perinatal HIV initiating de novo antiretroviral therapy.AIDS (London, England) · 2020Article
- Challenges and facilitators of transition from adolescent to adult HIV care among young adults living with HIV in Moshi, Tanzania.Journal of the International AIDS Society · 2019Article
- The burden of oral conditions among adolescents living with HIV at a clinic in Johannesburg, South Africa.PloS one · 2019Article
- Prospective memory in youth with perinatally-acquired HIV infection.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2018Article
- The global epidemiology of adolescents living with HIV: time for more granular data to improve adolescent health outcomes.Current opinion in HIV and AIDS · 2018Review
- Associations between executive functioning and adherence in pediatric celiac disease.Children's health care : journal of the Association for the Care of Children's HealthArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundMedication adherence is a critical but challenging developmental task for children and adolescents with perinatally acquired HIV (PHIV). Understanding how medication responsibility, executive functions (EFs) and adaptive functioning (AF) influence adherence may help prepare adolescents for transition to adulthood.
methodsParticipants included PHIV children and adolescents 7-16 years of age enrolled in the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol, who were prescribed antiretroviral medications. Measures included caregiver report and child self-report measures of adherence, medication responsibility and EF, caregiver report of child AF, examiner-administered tests of EF and processing speed and demographic and health characteristics.
resultsTwo hundred fifty-six participants with PHIV (mean age: 12 years old) were 51% female, 80% black and 79% non-Hispanic. Per 7-day recall, 72% were adherent (no missed doses). Children/adolescents self-reported that 22% had sole and 55% had shared medication responsibility. Adjusted logistic models revealed significantly higher odds of adherence with sole caregiver responsibility for medication [odds ratio (OR): 4.10, confidence interval (CI): 1.43-11.8, P = 0.009], child nadir CD4% <15% (OR: 2.26, CI: 1.15-4.43, P = 0.018), better self-reported behavioral regulation (OR: 0.65, CI: 0.44-0.96, P = 0.029) and slower processing speed (OR: 0.54, CI: 0.38-0.77, P < 0.001), adjusting for demographic variables (age, race and caregiver education).
conclusionsAmong children and adolescents with PHIV, continued caregiver medication management, especially during adolescence, is essential. Although global EF and AF were not significantly associated with adherence, behavioral regulation was. Given that EF and AF develop throughout adolescence, their relationships to adherence should be evaluated longitudinally, especially as youth transition to adulthood and caregiver responsibility diminishes.
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Registered trials
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