ArticleEnvironmental research2017
Vegetated land cover near residence is associated with reduced allostatic load and improved biomarkers of neuroendocrine, metabolic and immune functions.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Green Environments for Sustainable Brains: Parameters Shaping Adaptive Neuroplasticity and Lifespan Neurosustainability-A Systematic Review and Future Directions.International journal of environmental research and public health · 2025Pooled it
- Neighborhood Access to the Built Environment and Allostatic Load: A Systematic Review of the Use of Geographic Information Systems.Public health reviews · 2024Pooled it
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- Discerning asthma endotypes through comorbidity mapping.Nature communications · 2022Pooled it
- Green Space and Health Equity: A Systematic Review on the Potential of Green Space to Reduce Health Disparities.International journal of environmental research and public health · 2021Pooled it
- Long-Term Exposure to Residential Greenspace and Healthy Ageing: a Systematic Review.Current environmental health reports · 2020Pooled it
- Green spaces and mortality: a systematic review and meta-analysis of cohort studies.The Lancet. Planetary health · 2019Pooled it
- The Urban Built Environment, Walking and Mental Health Outcomes Among Older Adults: A Pilot Study.Frontiers in public health · 2020Trial
- Green space exposure predicts manic episodes in bipolar disorder: one year longitudinal analysis using smartphone-derived GPS data.Npj mental health research · 2026Article
- Relations of residential greenness with immunity and inflammation.Environmental research · 2026Article
- Satellite and ground-level residential greenness and hair steroid hormones during pregnancy.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Residential tree canopy and allostatic load in US adults: a population-based cross-sectional study.Lancet regional health. Americas · 2026Article
- The mortality impacts of implementing the 3-30-300 greenness rule and the WHO air quality guidelines in Bari, Southern Italy.Scientific reports · 2026Article
- Associations of access to exercise opportunities and physical inactivity with cardiovascular-kidney-metabolic mortality: a nationwide ecological study.Frontiers in public health · 2026Article
- Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026Review
- Effect of green space in the workplace on hearing thresholds in noise exposed population.Scientific reports · 2025Article
- Prenatal green space exposure and child's cognition: mediation by cord blood IGF1 in the ENVIRONAGE birth cohort.Environment international · 2025Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- Does a microbial-endocrine interplay shape love-associated emotions in humans? A hypothesis.mSystems · 2025Review
- Residential greenness and diabetes incidence in two prospective cohorts of US women.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGreater exposure to urban green spaces has been linked to reduced risks of depression, cardiovascular disease, diabetes and premature death. Alleviation of chronic stress is a hypothesized pathway to improved health. Previous studies linked chronic stress with a biomarker-based composite measure of physiological dysregulation known as allostatic load.
objectiveThis study's objective was to assess the relationship between vegetated land cover near residences and allostatic load.
methodsThis cross-sectional population-based study involved 206 adult residents of the Durham-Chapel Hill, North Carolina metropolitan area. Exposure was quantified using high-resolution metrics of trees and herbaceous vegetation within 500m of each residence derived from the U.S. Environmental Protection Agency's EnviroAtlas land cover dataset. Eighteen biomarkers of immune, neuroendocrine, and metabolic functions were measured in serum or saliva samples. Allostatic load was defined as a sum of potentially unhealthy biomarker values dichotomized at 10th or 90th percentile of sample distribution. Regression analysis was conducted using generalized additive models with two-dimensional spline smoothing function of geographic coordinates, weighted measures of vegetated land cover allowing decay of effects with distance, and geographic and demographic covariates.
resultsAn inter-quartile range increase in distance-weighted vegetated land cover was associated with 37% (95% Confidence Limits 46%; 27%) reduced allostatic load; significantly reduced adjusted odds of having low level of norepinephrine, dopamine, and dehydroepiandrosterone, and high level of epinephrine, fibrinogen, vascular cell adhesion molecule-1, and interleukin-8 in serum, and α-amylase in saliva; and reduced odds of previously diagnosed depression.
conclusionsThe observed effects of vegetated land cover on allostatic load and individual biomarkers are consistent with prevention of depression, cardiovascular disease and premature mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.