ArticleJournal of hypertension2017
Identifying unilateral disease in Chinese patients with primary aldosteronism by using a modified prediction score.
Article in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Assessment, External Verification and Modification of Models in Diagnosing Primary Aldosteronism Subtypes.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Prediction Model and Score for Subtyping Primary Aldosteronism: Development and Multi-Cohort Validation.JACC. Asia · 2026Article
- Machine learning-based prediction of primary aldosteronism subtype using comprehensive clinical features.Scientific reports · 2026Article
- Emerging methods for subtype differentiation in primary aldosteronism.Journal of internal medicine · 2026Review
- Identifying unilateral aldosterone-producing adenomas using published algorithms and imaging: a systematic review and meta-analysis.Endocrine connections · 2025Article
- Predicting Unilateral Aldosterone Secretion in Primary Aldosteronism.The Journal of surgical research · 2025Article
- Development and validation of prediction models for special subtype of primary aldosteronism: patients with negative adrenal CT imaging.Frontiers in endocrinology · 2025Article
- A predictive nomogram for incomplete clinical success after unilateral adrenalectomy in patients with primary aldosteronism.Frontiers in endocrinology · 2025Article
- The impact of a primary aldosteronism predictive model in secondary hypertension decision support.JAMIA open · 2024Article
- Clinical prediction model for primary aldosteronism subtyping and special focus on adrenal volumetric assessment.Hormones (Athens, Greece) · 2024Article
- Accuracy of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism.JAMA network open · 2023Article
- Sex modifies the predictive value of computed tomography combined with serum potassium for primary aldosteronism subtype diagnosis.Frontiers in endocrinology · 2023Article
- Primary aldosteronism - a multidimensional syndrome.Nature reviews. Endocrinology · 2022Review
- External Validation of Clinical Prediction Models in Unilateral Primary Aldosteronism.American journal of hypertension · 2022Article
- Outcome-Based Decision-Making Algorithm for Treating Patients with Primary Aldosteronism.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.Biomedicines · 2021Review
- Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe current study aimed to evaluate the role of Küpers' score in predicting unilateral aldosteronism, and develop a modified score in Chinese patients with primary aldosteronism.
methodsThe current retrospective study included 406 patients with primary aldosteronism who underwent successful adrenal venous sampling (AVS) and were divided into the unilateral (n = 211) and bilateral (n = 195) groups according to the AVS results. Normokalemia was noted in both the unilateral (n = 64) and bilateral groups (n = 84) when plasma and urinary aldosterone were measured.
resultsWe evaluated Küpers' prediction score, which had the best cutoff value at four points [area under the curve, 0.601 (95% confidence interval 0.551-0.650); specificity, 53%; sensitivity, 62%]. Then, we modified this score by using urinary aldosterone level quartiles, history of hypokalemia, and typical adenoma more than 10 mm on computed tomography (CT) [area under the curve, 0.745 (95% confidence interval 0.667-0.813)]; sensitivity, 45.3%; specificity, 90.5%). The best cutoff value to discriminate unilateral from bilateral disease was a score of 5. This modified prediction score only applied to patients who were normokalemic when urinary aldosterone was measured. A specificity of 100% was achieved at a score of 6 for patients aged 40 years or less, and 5 when the adrenal lesion was on the right side on CT imaging.
conclusionKüpers' prediction score is not suitable for our patients. Urinary aldosterone levels combined with a history of hypokalemia are useful to discriminate unilateral from bilateral aldosteronism in patients with typical adenoma on the right adrenal gland on CT or in patients 40 years old or less.
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