Evidence map›Paper›PMID 28708479›Full record

ReviewCleveland Clinic journal of medicine2017

The essential role of exercise in the management of type 2 diabetes.

John P Kirwan, Jessica Sacks, Stephan Nieuwoudt

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Cleveland Clinic journal of medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 215 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06518486 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effectiveness of Foot-Ankle Exercise and Walking Exercise on Foot Neuropathy, Stress, Quality of Life, Blood Sugar Markers, Blood Pressure, Ankle-Brachial Index, and BMI Among Diabetes Mellitus Patients

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2025Enrolled375ConditionsDiabetic Foot, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diabetes Type 2ArmsFoot-ankle exercise, Walking exercise, Usual care and health education
NCT06956664 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Efficacy of Physiotherapeutic Exercise Regimens Implemented After Caudal Epidural Steroid Injection

TypeinterventionalSponsorÇankırı Karatekin UniversityRan2025 to 2026Enrolled42ConditionsIntervertebral Disc Displacement, Low Back Pain, RadiculopathyArmsConventional Physiotherapy, Aerobic Exercise Programme, Core-Stabilization Exercise Programme
NCT07270328 nacompletednot on this mapstarted 2024, after this paper: background citation

A Pilot Study of Feasibility and Exploratory Study for a Definitive Randomised Controlled Trial of Foot-Ankle Versus Walking Exercises in Patients With Diabetes Mellitus: Effects on Neuropathy, Stress, and Quality of Life

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2024Enrolled108ConditionsDiabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic FootArmsFoot-ankle exercise group, Walking exercise group, Control group
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  17. Acute Effects of High-Intensity Interval Training on Diabetes Mellitus: A Systematic Review.International journal of environmental research and public health · 2022
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155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John P KirwanDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. kirwanj@ccf.org.
Jessica SacksDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Stephan NieuwoudtDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Role and Regulation of Skeletal Muscle Mitochondrial Dynamics in Type 2 DiabetesR01DK108089 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JOHN P. KIRWAN · 2015 to 2026
$4.9M
Lifestyle Intervention in Preparation for Pregnancy (LIPP)R01HD088061 · NICHD · TUFTS MEDICAL CENTER · PI CATALANO, PATRICK, KIRWAN, JOHN P. · 2017 to 2022
$3.6M
ARMMS-T2DU34DK107917 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRWAN, JOHN P., SCHAUER, PHILIP RAYMOND · 2015 to 2016
$731k
Role of the skeletal muscle/pancreatic axis in type 2 diabetesR21AR067477 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRWAN, JOHN P. · 2015 to 2016
$378k
NCATS NIH HHS UL1 TR000439NIAMS NIH HHS R21 AR067477NICHD NIH HHS R01 HD088061NIDDK NIH HHS R01 DK108089NIDDK NIH HHS U34 DK107917
6 · The paper itself

Abstract

Exercise is typically one of the first management strategies advised for patients newly diagnosed with type 2 diabetes. Together with diet and behavior modification, exercise is an essential component of all diabetes and obesity prevention and lifestyle intervention programs. Exercise training, whether aerobic or resistance training or a combination, facilitates improved glucose regulation. High-intensity interval training is also effective and has the added benefit of being very time-efficient. While the efficacy, scalability, and affordability of exercise for the prevention and management of type 2 diabetes are well established, sustainability of exercise recommendations for patients remains elusive.

Indexed as

AdultBlood GlucoseDiabetes Mellitus, Type 2ExerciseExercise TherapyFemaleHumansMaleBlood Glucose

Identifiers

PMID28708479
PMCPMC5846677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.