ArticleAmerican journal of respiratory and critical care medicine2017
Signs of Gas Trapping in Normal Lung Density Regions in Smokers.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Imaging in Chronic Obstructive Pulmonary Disease: Ready for Prime Time?Tuberculosis and respiratory diseases · 2026Article
- Airway tapering in COPD.The European respiratory journal · 2024Article
- SPECT/CT to quantify early small airway disease and its relationship to clinical symptoms in smokers with normal lung function: a pilot study.Frontiers in physiology · 2024Article
- The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2023Review
- Computer-assisted evaluation of small airway disease in CT scans of Iran-Iraq war victims of chemical warfare by a locally developed software: comparison between different quantitative methods.BMC medical imaging · 2023Article
- Computed Tomography Lung Density Analysis: An Imaging Biomarker Predicting Physical Inactivity in Chronic Obstructive Pulmonary Disease: A Pilot Study.Journal of clinical medicine · 2023Article
- Prognostic Biomarkers Based on Proteomic Technology in COPD: A Recent Review.International journal of chronic obstructive pulmonary disease · 2023Review
- Association of CT phenotype with pulmonary function in patients with chronic obstructive pulmonary disease and influencing factors of prognosis.American journal of translational research · 2023Article
- Bullous Parametric Response Map for Functional Localization of COPD.Journal of digital imaging · 2022Article
- Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre-Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward.American journal of respiratory and critical care medicine · 2022Review
- Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children.PloS one · 2022Article
- Structural airway imaging metrics are differentially associated with persistent chronic bronchitis.Thorax · 2021Article
- Article
- Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.The Lancet. Respiratory medicine · 2020Article
- Imaging Advances in Chronic Obstructive Pulmonary Disease. Insights from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) Study.American journal of respiratory and critical care medicine · 2019Review
- Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2019Review
- Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.American journal of respiratory and critical care medicine · 2018Review
- Update in Chronic Obstructive Pulmonary Disease 2017.American journal of respiratory and critical care medicine · 2018Article
- Lung volumes identify an at-risk group in persons with prolonged secondhand tobacco smoke exposure but without overt airflow obstruction.BMJ open respiratory research · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleA substantial proportion of subjects without overt airflow obstruction have significant respiratory morbidity and structural abnormalities as visualized by computed tomography. Whether regions of the lung that appear normal using traditional computed tomography criteria have mild disease is not known.
objectivesTo identify subthreshold structural disease in normal-appearing lung regions in smokers.
methodsWe analyzed 8,034 subjects with complete inspiratory and expiratory computed tomographic data participating in the COPDGene Study, including 103 lifetime nonsmokers. The ratio of the mean lung density at end expiration (E) to end inspiration (I) was calculated in lung regions with normal density (ND) by traditional thresholds for mild emphysema (-910 Hounsfield units) and gas trapping (-856 Hounsfield units) to derive the ND-E/I ratio. Multivariable regression analysis was used to measure the associations between ND-E/I, lung function, and respiratory morbidity. MEASUREMENTS AND MAIN
resultsThe ND-E/I ratio was greater in smokers than in nonsmokers, and it progressively increased from mild to severe chronic obstructive pulmonary disease severity. A proportion of 26.3% of smokers without airflow obstruction had ND-E/I greater than the 90th percentile of normal. ND-E/I was independently associated with FEV
conclusionsSubthreshold gas trapping representing mild small airway disease is prevalent in normal-appearing lung regions in smokers without airflow obstruction, and it is associated with respiratory morbidity. Clinical trial registered with www.clinicaltrials.gov (NCT00608764).
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