Evidence map›Paper›PMID 28707500›Full record

ReviewMolecular imaging

Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy.

Samit Chatterjee, Wojciech G Lesniak, Sridhar Nimmagadda

Open access · goldAbstract readReview
In one paragraph

Review in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Noninvasive ImmunoPET imaging of PD-L1 expression in non-small cell lung cancer and bladder cancer using [Colloids and surfaces. A, Physicochemical and engineering aspects · 2025
    Article
  3. EJNMMI research · 2025
    Article
  4. Synthesis and Evaluation of [Pharmaceutics · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Image-guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  20. [Progress in Neoadjuvant Immunotherapies for Resectable Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Samit Chatterjee1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA.
Wojciech G Lesniak1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA.
Sridhar Nimmagadda1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Imaging and targeting metastatic diseaseR01CA166131 · NCI · JOHNS HOPKINS UNIVERSITY · PI NIMMAGADDA, SRIDHAR · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA166131
6 · The paper itself

Abstract

Immunotherapy holds great promise in cancer treatment. The challenges in advancing immunotherapies lie in patient stratification and monitoring therapy. Noninvasive detection of immune checkpoint ligand PD-L1 can serve as an important biomarker for guidance and monitoring of immunotherapy. Here in, we provide an overview of our efforts to develop clinically translatable PD-L1-specific imaging agents for quantitative and real-time assessment of PD-L1 expression in tumor microenvironment.

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedB7-H1 AntigenBiomarkers, TumorHumansImmunotherapyPositron Emission Tomography Computed TomographyTomography, Emission-Computed, Single-PhotonAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedatezolizumabB7-H1 AntigenBiomarkers, TumorCd274 protein, mouseatezolizumabimmunotherapyoptical imagingPD-1peptidePETSPECT

Identifiers

PMID28707500
PMCPMC5676497
OpenAlexW2767777133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.