ArticleCancer medicine2017
Hormone factors play a favorable role in female head and neck cancer risk.
Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06100692 (Effect of Prophylactic Use of Oral Vitamin D and Zinc in Management of the Severity of Radiation Induced Oral Mucositis of Head and Neck Cancer Patients), which is not on this map. Cited by 40 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Prophylactic Use of Oral Vitamin D and Zinc in Management of the Severity of Radiation Induced Oral Mucositis of Head and Neck Cancer Patients
Who cites it
40 citing papers in PubMed.
- Rebamipide gargle and benzydamine gargle in prevention and management of chemo-radiotherapy and radiotherapy-induced oral mucositis in head and neck cancer patients (randomized clinical trial).BMC oral health · 2024Trial
- Tongue cancer in pregnancy: challenges and outcomes. A case series and review of the literature.Oral and maxillofacial surgery · 2025Review
- Article
- Testosterone and Androgen Receptor in Cancers with Significant Sex Dimorphism in Incidence Rates and Survival.Cancers · 2025Review
- Epidemiological trends in laryngeal cancer burden: insights from GBD 2021 and SEER databases.Discover oncology · 2025Article
- Global variations and socioeconomic inequalities in lifetime risk of lip, oral cavity, and pharyngeal cancer: a population-based systematic analysis of GLOBOCAN 2022.International journal of surgery (London, England) · 2025Article
- Oxidative Stress Biomarkers in Laryngeal Squamous Cell Carcinoma and Their Clinical Implications: Preliminary Results.Biomedicines · 2025Article
- Mortality of Head and Neck Cancer in China From 1990 to 2019: A Secondary Data Analysis.Cancer reports (Hoboken, N.J.) · 2025Article
- Article
- Article
- Global, regional, and national larynx cancer burden and health inequality analysis from 1990 to 2021 with a prediction from 2022 to 2040.Frontiers in oncology · 2025Article
- Burden of lip and oral cavity cancer among young people across South, East, and Southeast Asia: trends from 1990 to 2021 and predictions to 2030.Frontiers in oncology · 2025Article
- Global burden and future trends of head and neck cancer: a deep learning-based analysis (1980-2030).PloS one · 2025Article
- Laryngeal Cancer in Women: Unveiling Gender-Specific Risk Factors, Treatment Challenges, and Survival Disparities.Current oncology (Toronto, Ont.) · 2024Review
- Advancements in Hyperspectral Imaging and Computer-Aided Diagnostic Methods for the Enhanced Detection and Diagnosis of Head and Neck Cancer.Biomedicines · 2024Review
- Review
- Review
- Global burden of head and neck cancers from 1990 to 2019.iScience · 2024Article
- Article
- Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study.BMC cancer · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking. Lower risk was observed in women who used hormone replacement therapy (HRT) (OR = 0.58; 95% CI: 0.34-0.77). Pregnancy (OR = 0.61; 95% CI: 0.42-0.90) and giving birth (OR = 0.59; 95% CI: 0.38-0.90) at <35 years of age were inversely associated with HNCs. An inverse association with HNC was observed with age at start of HRT use (OR = 0.59; 95% CI: 0.39-0.90) for each additional 10 years and with duration of use (OR = 0.87; 95% CI: 0.76-0.99 for every 3 years). Exogenous female hormone use is associated with a nearly twofold risk reduction in female HNCs. The lower female HNC incidence may, in part, be explained by endogenous and exogenous estrogen exposures.
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