ArticleDevelopment, growth & differentiation2017
Mechanical role of the spatial patterns of contractile cells in invagination of growing epithelial tissue.
Article in Development, growth & differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Modeling of viscous frictional force in multicellular morphogenesis.Biophysics and physicobiology · 2026Article
- Organoid-Based Human Stomach Micro-Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Mechanical regulation of cell-cycle progression and division.Trends in cell biology · 2022Review
- Impact of environmental asymmetry on epithelial morphogenesis.Scientific reports · 2022Article
- Epithelial tissue folding pattern in confined geometry.Biomechanics and modeling in mechanobiology · 2020Article
- An energy landscape approach to understanding variety and robustness in tissue morphogenesis.Biomechanics and modeling in mechanobiology · 2020Article
- Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.Science advances · 2018Article
- Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial invagination is one of the fundamental deformation modes during morphogenesis, and is essential for deriving the three-dimensional shapes of organs from a flat epithelial sheet. Invagination occurs in an orderly manner according to the spatial pattern of the contractile cells; however, it remains elusive how tissue deformation can be caused by cellular activity in the patterned region. In this study, we investigated the mechanical role of the spatial patterns of the contractile cells in invagination of growing tissue using multicellular dynamics simulations. We found that cell proliferation and apical constriction were responsible for expanding the degree of tissue deformation and determining the location of the deformation, respectively. The direction of invagination depended on the spatial pattern of the contractile cells. Further, comparing the simulation results of surface and line contractions as possible modes of apical constriction, we found that the direction of invagination differed between these two modes even if the spatial pattern was the same. These results indicate that the buckling of the epithelial cell sheet caused by cell proliferation causes the invagination, with the direction and location determined by the configuration of the wedge-shaped cells given by the spatial pattern of the contractile cells.
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Registered trials
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