Evidence map›Paper›PMID 28707287›Full record

ArticleMolecular diagnosis & therapy2017

Are the Origins of Precision Medicine Found in the Corpus Hippocraticum?

Meropi K Konstantinidou, Makrina Karaglani, Maria Panagopoulou, Aliki Fiska, Ekaterini Chatzaki

Abstract readHistorical Article
PubMed Publisher
In one paragraph

Article in Molecular diagnosis & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Individualized pharmacotherapy: background and development.Annals of translational medicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Embracing the Wisdom of Ancient Greece in the Era of Personalized Medicine-Uncertainty, Probabilistic Reasoning, and Democratic Consensus.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  6. Article
  7. One step forward to personalized medicine?Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meropi K KonstantinidouLaboratory of History of Medicine, Faculty of Medicine, Democritus University of Thrace, Dragana, Alexandroupolis, Thrace, Greece.
Makrina KaraglaniLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace (DUTH), Dragana, Alexandroupolis, 68100, Thrace, Greece.
Maria PanagopoulouLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace (DUTH), Dragana, Alexandroupolis, 68100, Thrace, Greece.
Aliki FiskaLaboratory of History of Medicine, Faculty of Medicine, Democritus University of Thrace, Dragana, Alexandroupolis, Thrace, Greece.
Ekaterini ChatzakiLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace (DUTH), Dragana, Alexandroupolis, 68100, Thrace, Greece. achatzak@med.duth.gr.ORCID 0000-0002-5832-4257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine (PM) is currently placed at the center of global attention following decades of research towards the improvement of medical practice. The subject of this study was to examine whether this trend had emerged earlier, in fact if the fundamentals of PM can be traced back to the ancient Greek era. For this reason, we studied the collection of all the Hippocratic texts, called the Corpus Hippocraticum, using original translations, and attempted an interpretation of the ancient authors in the context of the modern concept of PM. The most important points located in the ancient passages were: (1) medicine in not 'absolute', thus its directions cannot be generalized to everybody, (2) each human body/organism is different and responds differently to therapy; therefore, the same treatment cannot be suitable for everybody and (3) the physician should choose the appropriate treatment, depending on the patients' individual characteristics, such as different health status and life style (activities, diet, etc.). Although the ancient 'precision medicine' is different from its modern description, the latter derived from well-established experimental conclusions, it becomes apparent that there is a common conception, aiming to achieve more effective healing by focusing on the individual.

Indexed as

History, AncientGreeceHumansPrecision Medicine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.