ArticleGeroScience2017
Multimodal physical activity increases brain-derived neurotrophic factor levels and improves cognition in institutionalized older women.
Article in GeroScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Physical and Motor Fitness Tests for Older Adults Living in Nursing Homes: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals.Nature human behaviour · 2020Pooled it
- Pooled it
- Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention.NeuroSci · 2026Review
- Brain-Derived Neurotrophic Factor (BDNF) as a Marker of Physical Exercise or Activity Effectiveness in Fatigue, Pain, Depression, and Sleep Disturbances: A Scoping Review.Biomedicines · 2025Review
- Development and Validation of the Communities Geriatric Mild Cognitive Impairment Risk Calculator (CGMCI-Risk).Healthcare (Basel, Switzerland) · 2024Article
- Relationship Between Physical Exercise and Cognitive Function Among Older Adults in China: Cross-Sectional Population-Based Study.JMIR public health and surveillance · 2024Article
- Article
- Physical exercise for brain plasticity promotion an overview of the underlying oscillatory mechanism.Frontiers in neuroscience · 2024Review
- Physical Exercise for Healthy Older Adults and Those with Frailty: What Exercise Is Best and Is There a Difference? A Systematic Review and Meta-Analyses.Current gerontology and geriatrics research · 2024Review
- Impact of Diet and Exercise Interventions on Cognition and Brain Health in Older Adults: A Narrative Review.Nutrients · 2023Review
- Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults: a quasi-experimental pilot study.Neural regeneration research · 2021Article
- Effects of physical exercise on working memory in older adults: a systematic and meta-analytic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2021Review
- BDNF Impact on Biological Markers of Depression-Role of Physical Exercise and Training.International journal of environmental research and public health · 2021Review
- Born to move: a review on the impact of physical exercise on brain health and the evidence from human controlled trials.Arquivos de neuro-psiquiatria · 2021Review
- Effect of Exercise on Major Depressive Disorder and Schizophrenia: A BDNF Focused Approach.Noro psikiyatri arsivi · 2019Review
- Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex.GeroScience · 2019Article
- Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice.GeroScience · 2019Article
- Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.American journal of physiology. Heart and circulatory physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity has been proposed as a promising intervention to improve cognition and decrease the risk of dementia in older adults. Brain-derived neurotrophic factor (BDNF) appears to mediate, at least partially, these effects of exercise. However, intervention studies of the effects of multimodal exercises on cognition and BDNF levels are scarce and composed by small samples. Thus, the generalization of the conclusions of these studies depends on the reproducibility of the results. In order to contribute to the knowledge on the field, the present study evaluated the effects of a physical activity intervention composed by muscle strengthening and aerobic conditioning on BDNF levels and cognition in older women. Independent and non-demented subjects (≥75 years) were assigned to a 3-month physical activity intervention (n = 22, 60 min exercise sessions three times a week) or to a control condition (n = 10, no exercise). Clinical (anxiety and depression symptoms), neuropsychological (Digit Span, Stroop, Trail Making, and Contextual Memory tests), physical (upper and lower limb strength, aerobic conditioning), and physiological (serum BDNF) parameters were evaluated immediately before, 1 month, and 3 months after starting intervention. Results indicated that controls had stable levels for all measured variables, whereas the intervention group improved on physical fitness, depressive symptoms, cognitive performance, and BDNF levels. Moreover, a linear regression identified an association between aerobic conditioning and BDNF levels. In conclusion, combined muscle strengthening and aerobic conditioning was able to improve cognitive performance and increase BDNF levels. Aerobic conditioning seems to be an important mediator of these outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.