Evidence map›Paper›PMID 28707224›Full record

ArticleIn vitro cellular & developmental biology. Animal2017

The influence of simulated microgravity on proliferation and apoptosis in U251 glioma cells.

Jiao Zhao, He Ma, Leitao Wu, Liang Cao, Qianqian Yang, Haijun Dong, Zongren Wang, Jing Ma, Zhen Li

Abstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Lipidomics of Caco-2 Cells Under Simulated Microgravity Conditions.International journal of molecular sciences · 2024
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiao ZhaoDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
He MaDepartment of Histology and Embryology, Fourth Military Medical University, Xi'an, Shaanxi, China.
Leitao WuDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Liang CaoDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Qianqian YangDepartment of Histology and Embryology, Fourth Military Medical University, Xi'an, Shaanxi, China.
Haijun DongDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zongren WangDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Jing MaDepartment of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. jingma@fmmu.edu.cn.
Zhen LiDepartment of Histology and Embryology, Fourth Military Medical University, Xi'an, Shaanxi, China. lizhenhe@fmmu.edu.cn.

Funding

National Natural Science Foundation of China NO.81273879
6 · The paper itself

Abstract

Several studies have indicated that microgravity can influence cellular progression, proliferation, and apoptosis in tumor cell lines. In this study, we observed that simulated microgravity inhibited proliferation and induced apoptosis in U251 malignant glioma (U251MG) cells. Furthermore, expression of the apoptosis-associated proteins, p21 and insulin-like growth factor binding protein-2 (IGFBP-2), was upregulated and downregulated, respectively, following exposure to simulated microgravity. These findings indicate that simulated microgravity inhibits proliferation while inducing apoptosis of U251MG cells. The associated effects appear to be mediated by inhibition of IGFBP-2 expression and stimulation of p21 expression. This suggests that simulated microgravity might represent a promising method to discover new targets for glioma therapeutic strategy.

Indexed as

Weightlessness SimulationApoptosisCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, NeoplasticGliomaHumansInsulin-Like Growth Factor Binding Protein 2CDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21IGFBP2 protein, humanInsulin-Like Growth Factor Binding Protein 2ApoptosisIGFBP-2Malignant gliomaP21Simulated microgravity

Identifiers

PMID28707224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.