Evidence map›Paper›PMID 28707182›Full record

ArticleInflammopharmacology2018

Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents.

Raphaelle Sousa Borges, Emerson Silva Lima, Hady Keita, Irlon Maciel Ferreira, Caio Pinho Fernandes, Rodrigo Alves Soares Cruz, Jonatas Lobato Duarte, Josué Velázquez-Moyado, Brenda Lorena Sánchez Ortiz, Andrés Navarrete Castro and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Immunomodulatory Effects of Medicinal Plants.Advances in experimental medicine and biology · 2026
    Review
  3. Synergistic Pain-Reducing Effects ofPharmaceuticals (Basel, Switzerland) · 2024
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  4. Hydroethanolic extracts fromPharmaceutical biology · 2024
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  5. Exploration of the anti-inflammatory potential ofFrontiers in pharmacology · 2024
    Article
  6. Article
  7. Review
  8. Acute Toxicity and Anti-Inflammatory Activity ofMolecules (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Article
  11. Potential Anti-Inflammatory Effect ofMolecules (Basel, Switzerland) · 2022
    Review
  12. Frontiers in pharmacology · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Raphaelle Sousa BorgesLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil. raphaellebio@yahoo.com.br.
Emerson Silva LimaLaboratório de Atividade Biológica - BIOPHAR, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio, 6200 - Coroado I, Manaus, AM, 69067-005, Brazil.
Hady KeitaLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil.
Irlon Maciel FerreiraLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil.
Caio Pinho FernandesLaboratório de Nanotecnologia Fitofarmacêutica, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Macapá, AP, Brazil.
Rodrigo Alves Soares CruzLaboratório de Nanotecnologia Fitofarmacêutica, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Macapá, AP, Brazil.
Jonatas Lobato DuarteLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil.
Josué Velázquez-MoyadoLaboratório de Farmacologia de Productos Naturales (LFPN), Facultat de Química, Universidad Nacional Autônoma de México (UNAM), Ciudad Universitária, 04510, México, DF, Mexico.
Brenda Lorena Sánchez OrtizLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil.
Andrés Navarrete CastroLaboratório de Farmacologia de Productos Naturales (LFPN), Facultat de Química, Universidad Nacional Autônoma de México (UNAM), Ciudad Universitária, 04510, México, DF, Mexico.
Jaderson Vieira FerreiraLaboratório de Química Farmacêutica e Medicinal (PharMedChem), Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Macapá, AP, Brazil.
Lorane Izabel da Silva Hage-MelimLaboratório de Química Farmacêutica e Medicinal (PharMedChem), Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Macapá, AP, Brazil.
José Carlos Tavares CarvalhoLaboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e Saúde, Universidade Federal do Amapá (UNIFAP), Rodovia Juscelino Kubitschek, S/N, Campus Marco Zero, Macapá, AP, CEP 68903-419, Brazil.
Universidade Federal do Amapá · BRUniversidad Nacional Autónoma de México · MXUniversidade Federal do Amazonas · BR

Funding

CAPES No. 3292/2013 AUXPECNPq Proc. 402332/2013-0
6 · The paper itself

Abstract

We evaluate the anti-inflammatory and antialgic potency of a nanoemulsion (NEORO) containing the essential oil of Rosmarinus officinalis L. (EORO), which is composed primarily of limonene, camphor and 1,8-cineole. The EORO and NEORO were administered orally 30 min prior to starting the experiments. In a test of rat paw oedema induced by carrageenan, NEORO was effective in doses of 498 µg/kg, and it inhibited 46% of the maximum peak of the oedema; in a dose of 300 mg/kg, EORO inhibited 50% of the maximum peak of the oedema. In an acetic acid-induced writhing test, NEORO yielded a dose-dependent effect, and a dose of 830 µg/kg inhibited 84% of the algesic process; a dose of 100 mg/kg of EORO inhibited 55%. In an assay for H

Indexed as

AnimalsAnti-Inflammatory AgentsCarrageenanCyclohexenesEdemaEmulsionsInflammationLimoneneMaleMolecular Docking SimulationNanoparticlesOils, VolatilePlant ExtractsRatsRats, WistarRosmarinusAnti-Inflammatory AgentsCarrageenanCyclohexenesEmulsionsLimoneneOils, VolatilePlant ExtractsTerpenesAntialgicAnti-inflammatoryH2SMolecular dockingNanoemulsionsRosmarinus officinalis

Identifiers

PMID28707182
OpenAlexW2734380220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.