ArticleNeuroradiology2017
Altered dynamic functional connectivity in the default mode network in patients with cirrhosis and minimal hepatic encephalopathy.
Article in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- The Effect of AoA-L2 on Functional Network Dynamics in Bilinguals.Brain topography · 2026Article
- Attenuated dietary motivation in Wilson's disease correlates with clinical severity.Orphanet journal of rare diseases · 2026Article
- Dynamic network reconfiguration in hepatitis B cirrhosis secondary to mild hepatic encephalopathy: a multilayer network analysis.Quantitative imaging in medicine and surgery · 2026Article
- Changes in dynamic and static brain fluctuation distinguish minimal hepatic encephalopathy and cirrhosis patients and predict the severity of liver damage.Frontiers in neuroscience · 2023Article
- Aberrant stability of brain functional architecture in cirrhotic patients with minimal hepatic encephalopathy.Brain imaging and behavior · 2022Article
- Dynamic functional network connectivity reveals the brain functional alterations in lung cancer patients after chemotherapy.Brain imaging and behavior · 2022Article
- Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.Scientific reports · 2022Article
- Altered dynamic spontaneous neural activity in minimal hepatic encephalopathy.Frontiers in neurology · 2022Article
- Radiomics-based classification models for HBV-related cirrhotic patients with covert hepatic encephalopathy.Brain and behavior · 2021Article
- Parcellation-based anatomic modeling of the default mode network.Brain and behavior · 2021Article
- Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study.Brain imaging and behavior · 2020Article
- Dynamic brain-body coupling of breath-by-breath O2-CO2 exchange ratio with resting state cerebral hemodynamic fluctuations.PloS one · 2020Article
- Altered dynamic effective connectivity of the default mode network in newly diagnosed drug-naïve juvenile myoclonic epilepsy.NeuroImage. Clinical · 2020Article
- Reduced Cortical Complexity in Cirrhotic Patients with Minimal Hepatic Encephalopathy.Neural plasticity · 2020Article
- Microstructural brain abnormalities correlate with neurocognitive dysfunction in minimal hepatic encephalopathy: a diffusion kurtosis imaging study.Neuroradiology · 2019Article
- Functional Network-Based Statistics Reveal Abnormal Resting-State Functional Connectivity in Minimal Hepatic Encephalopathy.Frontiers in neurology · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeAbnormal brain intrinsic functional connectivity (FC) has been documented in minimal hepatic encephalopathy (MHE) by static connectivity analysis. However, changes in dynamic FC (dFC) remain unknown. We aimed to identify altered dFC within the default mode network (DMN) associated with MHE.
methodsResting-state functional MRI data were acquired from 20 cirrhotic patients with MHE and 24 healthy controls. DMN seed regions were defined using seed-based FC analysis (centered on the posterior cingulate cortex (PCC)). Dynamic FC architecture was calculated using a sliding time-window method. K-means clustering (number of clusters = 2-4) was applied to estimate FC states.
resultsWhen the number of clusters was 2, MHE patients presented weaker connectivity strengths compared with controls in states 1 and 2. In state 1, decreased FC strength was found between the PCC/precuneus (PCUN) and right medial temporal lobe (MTL)/bilateral lateral temporal cortex (LTC); left inferior parietal lobule (IPL) and right MTL/left LTC; right IPL and right MTL/bilateral LTC; right MTL and right LTC; and medial prefrontal cortex (MPFC) and right MTL/bilateral LTC. In state 2, reduced FC strength was observed between the PCC/PCUN and bilateral MTL/bilateral LTC; left IPL and left MTL/bilateral LTC/MPFC; and left LTC and right LTC. Altered connectivities from state 1 were correlated with patient cognitive performance. Similar findings were observed when the number of clusters was set to 3 or 4.
conclusionAberrant dynamic DMN connectivity is an additional characteristic of MHE. Dynamic connectivity analysis offers a novel paradigm for understanding MHE-related mechanisms.
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