Evidence map›Paper›PMID 28707025›Full record

ArticleAIDS and behavior2018

Interest in Long-Acting Injectable PrEP in a Cohort of Men Who have Sex with Men in China.

Kathrine Meyers, Yumeng Wu, Haoyu Qian, Theodorus Sandfort, Xiaojie Huang, Junjie Xu, Jing Zhang, Wei Xia, David Glidden, Hao Wu and 1 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Frontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathrine MeyersAaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA.
Yumeng WuAaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA.
Haoyu QianAaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA.
Theodorus SandfortHIV Center for Clinical and Behavioral Studies, Columbia University, New York, NY, USA.
Xiaojie HuangCenter for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Junjie XuKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China.
Jing ZhangKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China.
Wei XiaCenter for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
David GliddenUniversity of California, San Francisco, CA, USA.
Hao WuCenter for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China. whdoc@sina.com.
Hong ShangKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China. hongshang100@hotmail.com.

Funding

The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure ProphylaxisR03AI122908 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLIDDEN, DAVID V. · 2016 to 2017
$159k
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic EffectsR03AI120819 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLIDDEN, DAVID V. · 2015 to 2016
$158k
NCATS NIH HHS UL1 TR001866NIAID NIH HHS R03 AI120819NIAID NIH HHS R03 AI122908NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

Long-acting injectable (LAI) formulations of antiretrovirals (ARVs) as pre-exposure prophylaxis (PrEP) could be an attractive alternative for men who have sex with men (MSM) who are interested in ARV-based biomedical prevention but will not use a daily pill. This study investigated interest in LAI-PrEP in a cohort of MSM in China and characterized how MSM willing to use only injectable PrEP differed from MSM who would use PrEP regardless of modality or not at all. Demographic, behavioral, and risk perception measures were collected and associations investigated. A licensed LAI-PrEP agent would increase the proportion interested in PrEP by 24.5% over oral PrEP alone. Combining interest in oral and injectable PrEP, 78.5% of the sample could be covered if reported interest in PrEP translated into actual uptake. Partnership factors differentiated those who would be willing to use only LAI-PrEP versus any PrEP modality, while higher self-perception of risk was associated with interest in LAI-PrEP versus no PrEP. The addition of a second PrEP modality could yield increased population coverage of PrEP. Social and behavioral research should be undertaken in parallel with clinical development of injectable PrEP agents to identify characteristics of those who are not interested in oral PrEP but would take advantage of ARV-based prevention with the introduction of an injectable product.

Indexed as

AdultAnti-HIV AgentsChinaCohort StudiesHIV InfectionsHomosexuality, MaleHumansInjectionsMalePatient Acceptance of Health CarePre-Exposure ProphylaxisAnti-HIV AgentsBiomedical HIV preventionChinaHIVLong-acting injectable PrEPMen who have sex with menPrEP

Identifiers

PMID28707025
PMCPMC5767147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.