ArticleJapanese journal of ophthalmology2017
Postoperative Enterococcus faecalis endophthalmitis: virulence factors leading to poor visual outcome.
Article in Japanese journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Dissemination of vancomycin-resistant Enterococcus faecalis and Enterococcus faecium between humans and fishes.Scientific reports · 2026Article
- Pathogen-Associated Visual Outcomes Following Postprocedure Endophthalmitis.American journal of ophthalmology · 2026Article
- Genomic Characterization of Multiple Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Comparison of Endophthalmitis Rates Between Prefilled Syringes and Standard Vials in Aflibercept Intravitreal Injections: A Retrospective Study in Japan.Journal of clinical medicine · 2025Article
- Disruption of the Enterococcus faecalis-Induced Biofilm on the Intraocular Lens Using Bacteriophages.Translational vision science & technology · 2024Article
- Phenotypic and genotypic characterization of Enterococcus faecalis and Enterococcus faecium isolated from fish, vegetables, and humans.Scientific reports · 2024Article
- Antimicrobial Resistance, Virulence Factors, and Genotypes ofAntibiotics (Basel, Switzerland) · 2023Article
- Review
- Intracameral Bacteriophage Injection as Postoperative Prophylaxis for Enterococcus faecalis-Induced Endophthalmitis After Cataract Surgery in Rabbits.Translational vision science & technology · 2022Article
- Article
- In Vitro and In Vivo Evaluation of Three Newly Isolated Bacteriophage Candidates, phiEF7H, phiEF14H1, phiEF19G, for Treatment ofMicroorganisms · 2021Article
- EmergingEmerging microbes & infections · 2020Article
- The cereus matter of Bacillus endophthalmitis.Experimental eye research · 2020Review
- Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis.Antimicrobial agents and chemotherapy · 2019Article
- Unusual microbiological presentations in polymicrobial post-operative endophthalmitis and their clinical correlations.International ophthalmology · 2019Article
- Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces.Japanese journal of ophthalmology · 2018Article
- Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis.PloS one · 2018Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose Postoperative endophthalmitis caused by Enterococcus faecalis often results in poor visual outcome due to retinal destruction. We evaluated the virulence factors of Enterococcus faecalis clinical isolates and analyzed their relationship with retinal destruction and poor visual outcomes in postoperative bacterial endophthalmitis (PBE) following cataract surgery. STUDY
designRetrospective.
methodsE. faecalis isolates from nine acute-onset PBE cases were examined using pulsed-field gel electrophoresis of genomic DNA, plasmid isolation and pheromone response experiments. Virulence determinant genes, including cytolysin (cylA), aggregation substance (asa1), enterococcal surface protein (esp), gelatinase (gelE) and adhesin of collagen from enterococci (ace), were examined by polymerase chain reaction. Expression of cytolysin and secreted protease were also tested. Retinal findings observed during vitrectomy surgery and final visual acuities were compared to obtained microbiological data. Poor visual outcome was defined as final visual acuity of less than 0.1 (decimal).
resultsAlthough nine isolates were collected, two were identical. Out of the eight different isolates, three were positive for both expressions of cytolysin and secreted proteases. Plasmid DNAs were isolated from six of eight isolates, while pheromone response was observed in five isolates. The asa1, esp and ace genes were positive in six, five and eight of the isolates, respectively. Patients with retinal destruction exhibited significantly higher prevalence of secreted protease expression versus those without (P < 0.05), and retinal destruction was related to poor visual outcome (P < 0.05).
conclusionsOur data suggest that enterococcal secreted proteases were correlated to retinal destruction, thereby fostering poor visual outcomes in eyes with enterococcal endophthalmitis.
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