ArticleScience immunology2017
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 129 citations in OpenAlex.
- Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion.The Journal of clinical investigation · 2021Trial
- EradicatingBioactive materials · 2026Article
- Review
- Organelle interplay in host responses and mycobacterial resilience.EMBO reports · 2026Review
- Sirtuin2 blockade inhibits replication of human immunodeficiency virus-1 and Mycobacterium tuberculosis in macrophages and humanized mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Article
- Post-TB lung disease: pathogenesis, host-directed therapies, and the C3HeB/FeJ model for pre-clinical advances.Infection and immunity · 2026Review
- Epigenetic modulation in tuberculosis - mycobacterial defense mechanism to host immune responses.Frontiers in immunology · 2026Review
- The pathway of autophagy in the epigenetic landscape ofAutophagy · 2025Review
- Host-directed therapeutic targets in macrophages and their ligands against mycobacteria tuberculosis.Infection and immunity · 2025Review
- Effect of urolithin A on intracellular survival ofmSphere · 2025Article
- Inducible antibacterial responses in macrophages.Nature reviews. Immunology · 2025Review
- Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities.Frontiers in cellular and infection microbiology · 2025Review
- Intraperitoneal Treatment of Cambinol, a Synthetic SIRT1 and SIRT2 Inhibitory Compound, ExacerbatesMicroorganisms · 2024Article
- Sirtuin inhibitors reduce intracellular growth of M. tuberculosis in human macrophages via modulation of host cell immunity.Scientific reports · 2024Article
- Epigenetic Mechanisms Induced byInternational journal of molecular sciences · 2024Review
- Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Tuberculosis-diabetes comorbidities: Mechanistic insights for clinical considerations and treatment challenges.World journal of diabetes · 2024Review
- The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival.Nature communications · 2023Article
- G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival.PLoS pathogens · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Catherine Y ChengSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Nuria M GutierrezDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Mardiana B MarzukiSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Xiaohua LuSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Taylor W ForemanTulane National Primate Research Center, Covington, LA 70433, USA.
Bhairav PalejaSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Bernett LeeSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Akhila BalachanderSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Jinmiao ChenSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Liana TsenovaPublic Health Research Institute of Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103, USA.
Natalia KurepinaPublic Health Research Institute of Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103, USA.
Karen W W TengSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Kim WestDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Smriti MehraLouisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA.
Francesca ZolezziSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Michael PoidingerSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Barry KreiswirthPublic Health Research Institute of Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103, USA.
Deepak KaushalTulane National Primate Research Center, Covington, LA 70433, USA.
Hardy KornfeldDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Evan W NewellSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Amit SinghalSingapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648, Singapore.
Agency for Science, Technology and Research · SGRutgers, The State University of New Jersey · USUniversity of Massachusetts Chan Medical School · USTulane University · USLouisiana State University · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MImpact of Diabetes and Hyperlipidemia on Host DefenseR01HL081149 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY · 2006 to 2019
$5.3MPerturbation of antigen-specific T cell responses in latent TB/SIV co-infectionR01AI111943 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2015 to 2019
$3.9MGenetic Requirements for the survival of Tubercle Bacilli in Nonhuman PrimatesR01AI089323 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2014
$3.2MTranscriptomics of Tuberculosis Latency and Reactivation in PrimatesR01HL106790 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2013
$3.1MNHLBI NIH HHS R01 HL081149NHLBI NIH HHS R01 HL106790NIAID NIH HHS R01 AI089323NIAID NIH HHS R01 AI111943NIH HHS P51 OD011104
Abstract
PubMed holds no abstract for this paper.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.