Evidence map›Paper›PMID 28706997›Full record

ArticleNature human behaviour2016

Childhood forecasting of a small segment of the population with large economic burden.

Avshalom Caspi, Renate M Houts, Daniel W Belsky, Honalee Harrington, Sean Hogan, Sandhya Ramrakha, Richie Poulton, Terrie E Moffitt

Abstract read
In one paragraph

Article in Nature human behaviour, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. A meta-analytic investigation of the role of reward on inhibitory control.Quarterly journal of experimental psychology (2006) · 2021
    Pooled it
  3. The Relationship between Family Violence and Self-Control in Adolescence: A Multi-Level Meta-Analysis.International journal of environmental research and public health · 2018
    Pooled it
  4. Trial
  5. Child Birth Order as a Moderator of Intervention Effectiveness for the Early Childhood Version of the Family Check-Up.Prevention science : the official journal of the Society for Prevention Research · 2020
    Trial
  6. Article
  7. A multilevel systems approach to resilience after childhood adversity.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Avshalom CaspiDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Renate M HoutsDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Daniel W BelskyDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA.
Honalee HarringtonDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Sean HoganDepartment of Psychology, University of Otago, Dunedin, New Zealand.
Sandhya RamrakhaDepartment of Psychology, University of Otago, Dunedin, New Zealand.
Richie PoultonDepartment of Psychology, University of Otago, Dunedin, New Zealand.
Terrie E MoffittDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Generating new knowledge to support reversibility interventionsR01AG048895 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2014 to 2015
$311k
NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG048895NIA NIH HHS R01 AG049789
6 · The paper itself

Abstract

Policy-makers are interested in early-years interventions to ameliorate childhood risks. They hope for improved adult outcomes in the long run, bringing return on investment. How much return can be expected depends, partly, on how strongly childhood risks forecast adult outcomes. But there is disagreement about whether childhood determines adulthood. We integrated multiple nationwide administrative databases and electronic medical records with the four-decade Dunedin birth-cohort study to test child-to-adult prediction in a different way, by using a population-segmentation approach. A segment comprising one-fifth of the cohort accounted for 36% of the cohort's injury insurance-claims; 40% of excess obese-kilograms; 54% of cigarettes smoked; 57% of hospital nights; 66% of welfare benefits; 77% of fatherless childrearing; 78% of prescription fills; and 81% of criminal convictions. Childhood risks, including poor age-three brain health, predicted this segment with large effect sizes. Early-years interventions effective with this population segment could yield very large returns on investment.

Identifiers

PMID28706997
PMCPMC5505663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.