Evidence map›Paper›PMID 28706974›Full record

ArticleTransplantation direct2017

Sirolimus Increases T-Cell Abundance in the Sun Exposed Skin of Kidney Transplant Recipients.

Michael Thomas Burke, Lauren C Sambira Nahum, Nicole M Isbel, Robert P Carroll, Hans Peter Soyer, Ross Francis, Jennifer Anne Bridge, Carmel Hawley, Kimberly Oliver, Christine E Staatz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael Thomas BurkeDepartment of Renal Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Lauren C Sambira NahumThe University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Brisbane, Australia.
Nicole M IsbelDermatology Research Centre, The University of Queensland, Faculty of Medicine, Translational Research Institute, Brisbane, Australia.
Robert P CarrollCentral Northern Adelaide Renal and Transplantation Services, Royal Adelaide Hospital, Adelaide, Australia.
Hans Peter SoyerDermatology Research Centre, The University of Queensland, Faculty of Medicine, Translational Research Institute, Brisbane, Australia.
Ross FrancisDepartment of Renal Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Jennifer Anne BridgeThe University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Brisbane, Australia.
Carmel HawleyDepartment of Renal Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Kimberly OliverDepartment of Anatomical Pathology, Princess Alexandra Hospital, Brisbane, Australia.
Christine E StaatzSchool of Pharmacy, University of Queensland, Brisbane, Australia.
James William WellsThe University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Brisbane, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplant recipients (KTRs) receiving the mammalian target of rapamycin inhibitor sirolimus may display a reduced risk of skin cancer development compared to KTRs receiving calcineurin inhibitors. Despite studies investigating the effects of these 2 drug classes on T cells in patient blood, the effect these drugs may have in patient skin is not yet known.

methodsFifteen patients with chronic kidney disease (not recipients of immunosuppressive drugs), and 30 KTRs (15 receiving a calcineurin inhibitor, and 15 receiving sirolimus) provided matched samples of blood, sun exposed (SE) and non-SE skin. The abundance of total CD8

resultsSirolimus treatment significantly increased absolute numbers of CD4

conclusionsThis study demonstrated that immunosuppressive drug class and sun exposure modify the abundance of multiple T-cell subsets in the skin of KTRs. Correlation analysis revealed that the prevalence of Treg cells in KTR blood does not accurately reflect the prevalence of Treg cells in KTR skin.

Identifiers

PMID28706974
PMCPMC5498012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.