ReviewNeural plasticity2017
The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain.
Review in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 380 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Smartphone Wellness App to Improve Mental Well-being: A Pilot Study
Transdiagnostic Cognitive Biomarkers
Pilot Randomized Trial of Health Coaching for People With Rheumatoid Arthritis to Improve Mental Well-Being
Who cites it
380 citing papers in PubMed, 9 syntheses or guidelines pooled it, 749 citations in OpenAlex.
- Potential Role of Botulinum Neurotoxin Type A as a Supportive Intervention for Depressive Symptoms: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Emerging trends and hotspots in cognitive behavioral therapy for chronic pain: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature.Pituitary · 2025Pooled it
- Anxiety, depression and acromegaly: a systematic review.Journal of endocrinological investigation · 2025Pooled it
- The influence of depression on clinical outcomes of total shoulder arthroplasty: a systematic Review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Dysmenorrhea and psychological distress: a meta-analysis.Archives of women's mental health · 2023Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Association between postpartum depression and chronic postsurgical pain after Cesarean delivery: a secondary analysis of a randomized trial.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Trial
- The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.BMC gastroenterology · 2025Trial
- Independent effects of transcranial direct current stimulation and social influence on pain.Pain · 2025Trial
- Music therapy with adult burn patients in the intensive care unit: short-term analysis of electrophysiological signals during music-assisted relaxation.Scientific reports · 2024Trial
- Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models.iScience · 2026Review
- De Novo Pain in Pregnancy: The Mediating Roles of Depression and Maternal-Fetal Attachment in De Novo Chronic Pain.European journal of pain (London, England) · 2026Article
- Occupational Stress, Nutritional Health, and Physical Pain Among Hong Kong Schoolteachers: A Cross-Sectional Study.Nutrients · 2026Article
- Neurobiological and Neuroimmune Mechanisms Linking Chronic Pain, Sleep Disturbances and Mental Health Disorders.International journal of molecular sciences · 2026Review
- Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine.Brain and behavior · 2026Review
- Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes.Psychopharmacology · 2026Article
- Therapeutic potential of CMPP, a novel maleimide derivative, in a reserpine-induced mouse model of pain-depression dyad.Biochemistry and biophysics reports · 2026Article
320 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression. In this review, we summarized the role of neuroplasticity in the occurrence and development of the two disorders in question and explored individualized application strategies of analgesic drugs and antidepressants that have different pharmacological effects in the treatment of chronic pain-induced depression. Therefore, this review may provide new insights into the understanding of association between chronic pain and depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.