Evidence map›Paper›PMID 28706692›Full record

ArticleChemical science2015

Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins.

Yousuke Takaoka, Yuki Nishikawa, Yuki Hashimoto, Kenta Sasaki, Itaru Hamachi

Abstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Precision Chemistry for Protein Lysine Modification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Advances in Proximity-Assisted Bioconjugation.Accounts of chemical research · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Sequence-Dependent Acylation of Peptide Lysine Residues by DNAzymes.Chembiochem : a European journal of chemical biology · 2024
    Article
  17. Ligand-Directed Labeling of the Adenosine AJournal of medicinal chemistry · 2024
    Article
  18. ACS chemical biology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yousuke TakaokaDepartment of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering Kyoto University , Katsura , Kyoto 615-8510 , Japan . Email: ihamachi@sbchem.kyoto-u.ac.jp ; ; Tel: +81-22-795-6557.
Yuki NishikawaDepartment of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering Kyoto University , Katsura , Kyoto 615-8510 , Japan . Email: ihamachi@sbchem.kyoto-u.ac.jp ; ; Tel: +81-22-795-6557.
Yuki HashimotoDepartment of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering Kyoto University , Katsura , Kyoto 615-8510 , Japan . Email: ihamachi@sbchem.kyoto-u.ac.jp ; ; Tel: +81-22-795-6557.
Kenta SasakiDepartment of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering Kyoto University , Katsura , Kyoto 615-8510 , Japan . Email: ihamachi@sbchem.kyoto-u.ac.jp ; ; Tel: +81-22-795-6557.
Itaru HamachiDepartment of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering Kyoto University , Katsura , Kyoto 615-8510 , Japan . Email: ihamachi@sbchem.kyoto-u.ac.jp ; ; Tel: +81-22-795-6557.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid and selective ligand-directed chemical reaction was developed for the acylation of proteins in living cells on the basis of ligand-directed chemistry. By fine tuning the reactivity and stability of the phenyl ester derivatives, we successfully identified

Identifiers

PMID28706692
PMCPMC5490417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.