Evidence map›Paper›PMID 28706661›Full record

ArticleChemical science2015

Controlled levels of protein modification through a chromatography-mediated bioconjugation.

Richard L Kwant, Jake Jaffe, Peter J Palmere, Matthew B Francis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Richard L KwantDepartment of Chemistry , University of California at Berkeley , Berkeley , California 94720-1460 , USA . Email: mbfrancis@berkeley.edu.
Jake JaffeDepartment of Chemistry , University of California at Berkeley , Berkeley , California 94720-1460 , USA . Email: mbfrancis@berkeley.edu.
Peter J PalmereDepartment of Chemistry , University of California at Berkeley , Berkeley , California 94720-1460 , USA . Email: mbfrancis@berkeley.edu.
Matthew B FrancisDepartment of Chemistry , University of California at Berkeley , Berkeley , California 94720-1460 , USA . Email: mbfrancis@berkeley.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetically modified proteins are increasingly finding applications as well-defined scaffolds for materials. In practice it remains difficult to construct bioconjugates with precise levels of modification because of the limited number of repeated functional groups on proteins. This article describes a method to control the level of protein modification in cases where there exist multiple potential modification sites. A protein is first tagged with a handle using any of a variety of modification chemistries. This handle is used to isolate proteins with a particular number of modifications

Identifiers

PMID28706661
PMCPMC5495134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.