ArticleChemical science2015
Functionalized graphene-based biomimetic microsensor interfacing with living cells to sensitively monitor nitric oxide release.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A magneto-responsive nanomesh biosensor for simultaneous mechanical stimulation and electrochemical detection.Nature communications · 2025Article
- Electrochemical Detection of Gasotransmitters: Status and Roadmap.ACS sensors · 2024Review
- Graphene nanocomposites for real-time electrochemical sensing of nitric oxide in biological systems.Applied physics reviews · 2023Article
- Planar carbon electrodes for real-time quantification of hydrogen sulfide release from cells.Sensors & diagnostics · 2023Article
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications.Biosensors · 2022Review
- Electrochemical microwell sensor with Fe-N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Article
- Recent Advances in Phthalocyanine and Porphyrin-Based Materials as Active Layers for Nitric Oxide Chemical Sensors.Sensors (Basel, Switzerland) · 2022Review
- CuO/Cu-MOF nanocomposite for highly sensitive detection of nitric oxide released from living cells using an electrochemical microfluidic device.Mikrochimica acta · 2021Article
- 2-Amino-3'-dialkylaminobiphenyl-based fluorescent intracellular probes for nitric oxide surrogate NChemical science · 2020Article
- Article
- Cellular Signaling Pathways Activated by Functional Graphene Nanomaterials.International journal of molecular sciences · 2018Review
- A sensitive acupuncture needle microsensor for real-time monitoring of nitric oxide in acupoints of rats.Scientific reports · 2017Article
- Two-color imaging of microRNA with enzyme-free signal amplificationChemical science · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is a great challenge to develop electrochemical sensors with superior sensitivity that concurrently possess high biocompatibility for monitoring at the single cell level. Herein we report a novel and reusable biomimetic micro-electrochemical sensor array with nitric oxide (NO) sensing-interface based on metalloporphyrin and 3-aminophenylboronic acid (APBA) co-functionalized reduced graphene oxide (rGO). The assembling of high specificity catalytic but semi-conductive metalloporphyrin with high electric conductive rGO confers the sensor with sub-nanomolar sensitivity. Further coupling with the small cell-adhesive molecule APBA obviously enhances the cytocompatibility of the microsensor without diminishing the sensitivity, while the reversible reactivity between APBA and cell membrane carbohydrates allows practical reusability. The microsensor was successfully used to sensitively monitor, in real-time, the release of NO molecules from human endothelial cells being cultured directly on the sensor. This demonstrates its potential application in the detection of NO with very low bioactive concentrations for the better understanding of its physiological function and for medical tracking of patient states.
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Registered trials
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