ArticleChemical science2015
Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Hydrolysis of 5-methylfuran-2-yl to 2,5-dioxopentanyl allows for stable bio-orthogonal proximity-induced ligation.Communications chemistry · 2021Article
- Expanding the scope of native chemical ligation - templated small molecule drug synthesisChemical science · 2021Article
- Visible-light triggered templated ligation on surface using furan-modified PNAs.Chemical science · 2020Article
- Templated chemistry for bioorganic synthesis and chemical biology.Journal of peptide science : an official publication of the European Peptide Society · 2019Review
- A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA editChemical science · 2018Article
- Simultaneous multiple single nucleotide polymorphism detection based on click chemistry combined with DNA-encoded probes.Chemical science · 2018Article
- Modular probes for enriching and detecting complex nucleic acid sequences.Nature chemistry · 2017Article
- Chemical ligation of oligonucleotides using an electrophilic phosphorothioester.Nucleic acids research · 2017Article
- Nucleic Acid Templated Reactions for Chemical Biology.ChemMedChem · 2017Review
- Fluorogenic Templated Reaction Cascades for RNA Detection.Journal of the American Chemical Society · 2017Article
- A stable bidentate protein binder achieved via DNA self-assembly driven ligand migration.Chemical communications (Cambridge, England) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several genomic disorders are caused by an excessive number of DNA triplet repeats. We developed a DNA-templated reaction in which product formation occurs only when the number of repeats exceeds a threshold indicative for the outbreak of Chorea Huntington. The combined use of native chemical PNA ligation and auxiliary DNA probes enabled reactions on templates obtained from human genomic DNA.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.