Evidence map›Paper›PMID 28706521›Full record

ReviewFrontiers in immunology2017

Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response.

Upasana Shokal, Ioannis Eleftherianos

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 117 citations in OpenAlex.

  1. Macrophage restriction inScience advances · 2026
    Article
  2. Article
  3. Article
  4. Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  5. Article
  6. Review
  7. Thioester-Containing Protein TEP27 inInternational journal of molecular sciences · 2025
    Article
  8. Cross-species protection suggestsInfection and immunity · 2025
    Article
  9. Article
  10. Article
  11. Comparative immunological roles of TEP1 inFrontiers in immunology · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Immune Responses of the Black Soldier FlyLife (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Upasana ShokalDepartment of Biological Sciences, The George Washington University, Washington, DC, United States.
Ioannis EleftherianosDepartment of Biological Sciences, The George Washington University, Washington, DC, United States.
George Washington University · US

Funding

Role of TGF-beta signaling in the Drosophila immune response against nematode-bacteria complexesR01AI110675 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI ELEFTHERIANOS, IOANNIS · 2015 to 2018
$954k
Developing genetic tools for a new model of infection and immunityR21AI109517 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI ELEFTHERIANOS, IOANNIS, HAWDON, JOHN M · 2014 to 2015
$431k
Role of TGF-Beta signaling in the Drosophila immune response against nematode-bacR56AI110675 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI ELEFTHERIANOS, IOANNIS · 2014 to 2014
$229k
NIAID NIH HHS R01 AI110675NIAID NIH HHS R21 AI109517NIAID NIH HHS R56 AI110675
6 · The paper itself

Abstract

The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the production of various molecules with antimicrobial activity. Thioester-containing proteins (TEPs) are a superfamily of secreted effector proteins. In vertebrates, certain TEPs act in the innate immune response by promoting recruitment of immune cells, phagocytosis, and direct lysis of microbial invaders. Insects are excellent models for dissecting the molecular basis of innate immune recognition and response to a wide range of microbial infections. Impressive progress in recent years has generated crucial information on the role of TEPs in the antibacterial and antiparasite response of the tractable model insect

Indexed as

complement systemDrosophilainnate immunityinsectsmammalsmosquitothioester-containing proteins

Identifiers

PMID28706521
PMCPMC5489563
OpenAlexW2625275851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.