Evidence map›Paper›PMID 28706493›Full record

ArticleFrontiers in physiology2017

Protein Phosphorylation and Mineral Binding Affect the Secondary Structure of the Leucine-Rich Amelogenin Peptide.

Hajime Yamazaki, Elia Beniash, Yasuo Yamakoshi, James P Simmer, Henry C Margolis

Abstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Amelogenin-Derived Peptides in Bone Regeneration: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. Article
  3. MnWorld journal of microbiology & biotechnology · 2024
    Article
  4. Article
  5. High-yield recombinant bacterial expression ofProtein science : a publication of the Protein Society · 2023
    Article
  6. Advanced materials for enamel remineralization.Frontiers in bioengineering and biotechnology · 2022
    Review
  7. Article
  8. A N-Terminus Domain Determines Amelogenin's Stability to Guide the Development of Mouse Enamel Matrix.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  9. Tooth Enamel and its Dynamic Protein Matrix.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hajime YamazakiCenter for Biomineralization, The Forsyth InstituteCambridge, MA, United States.
Elia BeniashDepartment of Oral Biology, Center for Craniofacial Regeneration, McGowan Institute for Regenerative Medicine, University of PittsburghPittsburgh, PA, United States.
Yasuo YamakoshiDepartment of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi UniversityYokohama, Japan.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of DentistryAnn Arbor, MI, United States.
Henry C MargolisCenter for Biomineralization, The Forsyth InstituteCambridge, MA, United States.

Funding

Structural determinants of amelogenin function in regulating enamel formationR01DE023091 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARGOLIS, HENRY C · 2013 to 2017
$3.0M
NIDCR NIH HHS R01 DE023091
6 · The paper itself

Abstract

Previously, we have shown that serine-16 phosphorylation in native full-length porcine amelogenin (P173) and the Leucine-Rich Amelogenin Peptide (LRAP(+P)), an alternative amelogenin splice product, affects protein assembly and mineralization

Indexed as

amelogenesisamelogeninFTIRleucine-rich amelogenin peptidesecondary structuretooth enamel

Identifiers

PMID28706493
PMCPMC5489624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.