ArticleFrontiers in neural circuits2017
Focal Stroke in the Developing Rat Motor Cortex Induces Age- and Experience-Dependent Maladaptive Plasticity of Corticospinal System.
Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of transcranial electrical stimulation combined with dual-task training in stroke, mild cognitive impairment and Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in human neuroscience · 2025Pooled it
- Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect.Neural plasticity · 2019Trial
- Developing a minimally invasive gene therapy for multiple sclerosis.Molecular therapy. Methods & clinical development · 2025Article
- Targeting thalamocortical circuits for closed-loop stimulation in Lennox-Gastaut syndrome.Brain communications · 2024Article
- Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.Neuroscience bulletin · 2022Review
- Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys.IBRO neuroscience reports · 2022Article
- Clinical Evaluation of Different Treatment Strategies for Motor Recovery in Poststroke Rehabilitation during the First 90 Days.Journal of clinical medicine · 2021Article
- Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats.Frontiers in neuroscience · 2020Article
- Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon.Current neurology and neuroscience reports · 2019Review
- Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain.Frontiers in neurology · 2019Review
- Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses.Neural plasticity · 2019Review
- Early impoverished environment delays the maturation of cerebral cortex.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor system development is characterized by an activity-dependent competition between ipsilateral and contralateral corticospinal tracts (CST). Clinical evidence suggests that age is crucial for developmental stroke outcome, with early lesions inducing a "maladaptive" strengthening of ipsilateral projections from the healthy hemisphere and worse motor impairment. Here, we investigated in developing rats the relation between lesion timing, motor outcome and CST remodeling pattern. We induced a focal ischemia into forelimb motor cortex (fM1) at two distinct pre-weaning ages: P14 and P21. We compared long-term motor outcome with changes in axonal sprouting of contralesional CST at red nucleus and spinal cord level using anterograde tracing. We found that P14 stroke caused a more severe long-term motor impairment than at P21, and induced a strong and aberrant contralesional CST sprouting onto denervated spinal cord and red nucleus. The mistargeted sprouting of CST, and the worse motor outcome of the P14 stroke rats were reversed by an early skilled motor training, underscoring the potential of early activity-dependent plasticity in modulating lesion outcome. Thus, changes in the mechanisms controlling CST plasticity occurring during the third postnatal week are associated with age-dependent regulation of the motor outcome after stroke.
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