ArticleJournal of laboratory physicians
Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study.
Article in Journal of laboratory physicians. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Neutrophils in cancer: from biology to therapy.Cellular & molecular immunology · 2025Review
- Case Report: Pitfalls in bone marrow evaluation: importance of adequate bone marrow sampling.Frontiers in oncology · 2025Article
- Comparison of plasma cell bone marrow counts by different methods in patients diagnosed with plasma cell disorders.Hematology, transfusion and cell therapy · 2024Article
- Engineered feature embeddings meet deep learning: A novel strategy to improve bone marrow cell classification and model transparency.Journal of pathology informatics · 2024Article
- Chronic Immune Thrombocytopenia Purpura Following COVID-19 Vaccination (ChAdOx1 -nCov-19): A Case Report With OneYear Follow-Up.Hospital pharmacy · 2024Article
- An Automated Pipeline for Differential Cell Counts on Whole-Slide Bone Marrow Aspirate Smears.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023Article
- The Profile of MicroRNA Expression in Bone Marrow in Non-Hodgkin's Lymphomas.Diagnostics (Basel, Switzerland) · 2022Article
- A Comparative Study of Bone Marrow Squash and Wedge Aspiration Smears.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Comparison of Bone Marrow Biopsy Specimens Obtained Using a Motorized Device and Manual Biopsy Systems.Asia-Pacific journal of oncology nursingArticle
- Diagnostic importance of bone marrow aspiration evaluation: A single-center study.Pakistan journal of medical sciencesArticle
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4 authors at 1 institution in 1 country.
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Abstract
introductionBone marrow examination is a useful investigative tool for the diagnosis of many hematological and nonhematological disorders. Bone marrow aspiration (BMA) provides information about the numerical and cytological features of marrow cells, whereas bone marrow trephine biopsies (BMB) provide excellent appreciation of spatial relationships between cells and of overall bone marrow structure. We conducted this study with the objective of comparing the accuracy of BMA with BMB in the diagnosis of various hematological disorders. MATERIALS AND
methodsBoth BMA and BMB were performed on a total of 130 cases and a comparative evaluation was performed in 100 cases to see the complementary role of both the procedures. However, 30 cases were excluded due to inadequate BMA, BMB, or both. Immunohistochemistry (IHC) was employed whenever required.
resultsIn our study of 100 cases, 87% of cases were confirmed on bone marrow biopsy and in remaining 13% of cases final diagnosis was achieved with the help of other ancillary investigations. These cases were excluded for calculation of concordance rate between BMA and BMB. The concordance and disconcordance rate between BMA and BMB was 72.4% and 27.6%, respectively.
conclusionBMA cytology and trephine biopsy histopathology complement each other and the superiority of one method over the other depended on the underlying disorder. Furthermore, application of ancillary techniques such as flow cytometery and IHC proved to be an additional advantage in further typing of various diseases.
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