Evidence map›Paper›PMID 28706185›Full record

ArticleScientific reports2017

Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR.

Stefano Trebeschi, Joost J M van Griethuysen, Doenja M J Lambregts, Max J Lahaye, Chintan Parmar, Frans C H Bakers, Nicky H G M Peters, Regina G H Beets-Tan, Hugo J W L Aerts

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 130 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Stefano TrebeschiDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-5714-289X
Joost J M van GriethuysenDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
Doenja M J LambregtsDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
Max J LahayeDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
Chintan ParmarDepartment of Radiation Oncology and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Frans C H BakersDepartment of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Nicky H G M PetersDepartment of Radiology, Zuyderland Medical Center, location Heerlen, Heerlen, The Netherlands.
Regina G H Beets-TanDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hugo J W L AertsDepartment of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands. Hugo_Aerts@dfci.harvard.edu.ORCID 0000-0002-2122-2003

Funding

Quantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5M
Genotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3M
NCI NIH HHS U01 CA190234NCI NIH HHS U24 CA194354
6 · The paper itself

Abstract

Multiparametric Magnetic Resonance Imaging (MRI) can provide detailed information of the physical characteristics of rectum tumours. Several investigations suggest that volumetric analyses on anatomical and functional MRI contain clinically valuable information. However, manual delineation of tumours is a time consuming procedure, as it requires a high level of expertise. Here, we evaluate deep learning methods for automatic localization and segmentation of rectal cancers on multiparametric MR imaging. MRI scans (1.5T, T2-weighted, and DWI) of 140 patients with locally advanced rectal cancer were included in our analysis, equally divided between discovery and validation datasets. Two expert radiologists segmented each tumor. A convolutional neural network (CNN) was trained on the multiparametric MRIs of the discovery set to classify each voxel into tumour or non-tumour. On the independent validation dataset, the CNN showed high segmentation accuracy for reader1 (Dice Similarity Coefficient (DSC = 0.68) and reader2 (DSC = 0.70). The area under the curve (AUC) of the resulting probability maps was very high for both readers, AUC = 0.99 (SD = 0.05). Our results demonstrate that deep learning can perform accurate localization and segmentation of rectal cancer in MR imaging in the majority of patients. Deep learning technologies have the potential to improve the speed and accuracy of MRI-based rectum segmentations.

Indexed as

Machine LearningAgedAutomationDeep LearningFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeural Networks, ComputerRectal Neoplasms

Identifiers

PMID28706185
PMCPMC5509680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.