ArticleStroke2017
Age-Specific Sex Differences in Magnetic Resonance Imaging-Depicted Carotid Intraplaque Hemorrhage.
Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Influence of a six-month home-based individualized physical activity intervention on carotid plaque instability measured by magnetic resonance imaging: a randomized controlled clinical trial.EClinicalMedicine · 2025Article
- Sex differences in features of atherosclerotic plaques as revealed by various imaging techniques: historical review.Frontiers in physiology · 2025Review
- Age-specific sex differences in intravascular ultrasound based coronary atherosclerotic plaque characteristics.American heart journal plus : cardiology research and practice · 2024Article
- Age-dependent sex differences in non-stenotic intracranial plaque of embolic stroke of undetermined source.Scientific reports · 2023Article
- Extracranial carotid plaque hemorrhage predicts ipsilateral stroke recurrence in patients with carotid atherosclerosis - a study based on high-resolution vessel wall imaging MRI.BMC neurology · 2022Article
- Update on Management of Cardiovascular Diseases in Women.Journal of clinical medicine · 2022Review
- Sex Differences in Intracranial Atherosclerotic Plaques Among Patients With Ischemic Stroke.Frontiers in cardiovascular medicine · 2022Article
- Gender dimension in cardio-pulmonary continuum.Frontiers in cardiovascular medicine · 2022Review
- Quantitative and qualitative features of carotid and coronary atherosclerotic plaque among men and women.Frontiers in cardiovascular medicine · 2022Review
- Vulnerable Plaque Is More Prevalent in Male Individuals at High Risk of Stroke: A Propensity Score-Matched Study.Frontiers in physiology · 2021Article
- Sonodynamic therapy reduces iron retention of hemorrhagic plaque.Bioengineering & translational medicine · 2021Article
- Magnetic resonance imaging of carotid plaques: current status and clinical perspectives.Annals of translational medicine · 2020Review
- Variations in the Presence of Carotid Intraplaque Hemorrhage Across Age Categories: What Age Groups Are Most Likely to Benefit From Plaque Imaging?Frontiers in neurology · 2020Article
- Proteomics and multivariate modelling reveal sex-specific alterations in distinct regions of human carotid atheroma.Biology of sex differences · 2018Article
- Hypertension and Organ Damage in Women.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
background and purposeStroke rates are higher in men compared with women in the fourth through seventh decades of life, and higher rates may result from differences in carotid intraplaque hemorrhage (IPH), an unstable atherosclerotic plaque component. We report age-specific sex differences in the presence of magnetic resonance imaging-depicted carotid IPH.
methodsPatients (n=1115) underwent magnetic resonance imaging for carotid IPH between 2005 and 2014. Low-grade carotid stenosis patients (n=906) without prior endarterectomy were eligible for this cross-sectional study.
resultsOf the 906 patients included (mean age±SD in years, 66.98±15.15), 63 (6.95%) had carotid IPH. In men and women, carotid IPH was present in 11.43% (48 of 420) and 3.09% (15 of 486), respectively (
conclusionsMen have greater age-specific odds of magnetic resonance imaging-depicted carotid IPH compared with women. With increasing age post-menopause, the odds of carotid IPH in women becomes closer to that of men. Delayed onset of carotid IPH in women, an unstable plaque component, may partly explain differential stroke rates between sexes, and further studies are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.