ArticleThe Biochemical journal2017
Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in The Biochemical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 68 citations in OpenAlex.
- Orchestrating glucose metabolism: PFKFB2 as a signal-integrating conductor in homeostasis and disease.The Journal of biological chemistry · 2026Review
- PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization.Journal of the American Heart Association · 2025Article
- An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress.Circulation · 2025Article
- Metabolic Adaptations and Therapies in Cardiac Hypoxia: Mechanisms and Clinical Implications/ Potential Strategies.JACC. Basic to translational science · 2025Review
- Phase partitioning of the neutrophil oxidative burst is coordinated by accessory pathways of glucose metabolism and mitochondrial activity.The Journal of biological chemistry · 2025Article
- Does Cell-Type-Specific Silencing of Monoamine Oxidase B Interfere with the Development of Right Ventricle (RV) Hypertrophy or Right Ventricle Failure in Pulmonary Hypertension?International journal of molecular sciences · 2024Article
- Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth.Journal of molecular and cellular cardiology · 2024Article
- Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart.Journal of the American Heart Association · 2024Article
- Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals.The Journal of biological chemistry · 2024Review
- Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise.Current heart failure reports · 2023Review
- Importance of Mitochondria in Cardiac Pathologies: Focus on Uncoupling Proteins and Monoamine Oxidases.International journal of molecular sciences · 2023Review
- Roles ofFrontiers in physiology · 2023Article
- Oncometabolism: A Paradigm for the Metabolic Remodeling of the Failing Heart.International journal of molecular sciences · 2022Review
- Glutamine uptake and catabolism is required for myofibroblast formation and persistence.Journal of molecular and cellular cardiology · 2022Article
- Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo.Communications biology · 2022Article
- Metabolic Determinants of Cardiomyocyte Proliferation.Stem cells (Dayton, Ohio) · 2022Article
- Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts.The Journal of clinical investigation · 2022Article
- The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology.Frontiers in endocrinology · 2022Review
- Extensive mitochondrial proteome disturbance occurs during the early stages of acute myocardial ischemia.Experimental and therapeutic medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Andrew A GibbInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A.
Pawel K LorkiewiczInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A.
Yu-Ting ZhengInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A.
Xiang ZhangDepartment of Chemistry, University of Louisville, Louisville, KY 40202, U.S.A.
Aruni BhatnagarInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A.
Steven P JonesInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A.
Bradford G HillInstitute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, U.S.A. bradford.hill@louisville.edu.
University of Louisville · US
Funding
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI GHARE, SMITA S · 2016 to 2025
$24.1MThe Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI SHIRISH S BARVE · 2016 to 2026
$17.9MProject 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8MTOXICITY OF 4-HYDROXYALKENALS IN HEARTR01HL055477 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BHATNAGAR, ARUNI · 1997 to 2015
$4.4MRegulation of Metabolic Genes in the HeartR01HL131647 · NHLBI · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2016 to 2019
$2.2MMetabolic optimization of cell therapyR01HL130174 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2016 to 2020
$1.9MO-GlcNAc Signaling in Heart FailureR01HL094419 · NHLBI · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2009 to 2012
$1.5MUltra Performance Liquid Chromatography High Resolution High Mass Accuracy Mass SpectrometerS10OD020106 · OD · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2015 to 2015
$600kMetabolic regulation of cardiac stem cellsR56HL122580 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2015 to 2015
$381kAmerican Heart Association-American Stroke Association 16PRE31010022NHLBI NIH HHS R01 HL055477NHLBI NIH HHS R01 HL094419NHLBI NIH HHS R01 HL130174NHLBI NIH HHS R01 HL131647NHLBI NIH HHS R56 HL122580NIAAA NIH HHS P50 AA024337NIGMS NIH HHS P20 GM103492NIGMS NIH HHS P20 GM113226NIH HHS S10 OD020106
Abstract
Although ancillary pathways of glucose metabolism are critical for synthesizing cellular building blocks and modulating stress responses, how they are regulated remains unclear. In the present study, we used radiometric glycolysis assays, [
Indexed as
GlycolysisPentose Phosphate PathwayAmino Acid SubstitutionAnimalsAnimals, NewbornCarbon IsotopesCells, CulturedCulture Media, Serum-FreeGlucoseGreen Fluorescent ProteinsHexosaminesLactic AcidMitochondria, MuscleMyocytes, CardiacOligopeptidesPhosphofructokinase-1, Liver TypeCarbon IsotopesCulture Media, Serum-Freeenhanced green fluorescent proteinFLAG peptideGlucoseGreen Fluorescent ProteinsHexosaminesLactic AcidOligopeptidesPhosphofructokinase-1, Liver Typephosphofructokinase-1 subunit, type LPyrimidinesPyruvic AcidRecombinant Fusion ProteinsUridine Diphosphatecardiac hypertrophyglycolysisheart failuremetabolomicsmitochondriastable isotope
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.