Evidence map›Paper›PMID 28705991›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2017

Oxygen metabolism and innate immune responses in the gut.

Sean P Colgan, Eric L Campbell

Open access · greenAbstract readReview
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sean P ColganDepartment of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado; and Sean.Colgan@UCDenver.edu.
Eric L CampbellCentre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.
Queen's University Belfast · GBUniversity of Colorado Denver · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Mechanisms of Adenosine ProtectionR01DK095491 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Sean P Colgan · 2012 to 2026
$4.9M
Metabolic Regulation of Inflammation by Microbial SCFAR01DK104713 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Sean P Colgan · 2015 to 2026
$4.7M
Hypoxia, HIF, and Mucosal InflammationR37DK050189 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLGAN, SEAN P · 2010 to 2019
$4.1M
PMN-EPITHELIAL CROSSTALK COORDINATES MONOCYTE POLARIZATION DURING INFLAMMATIONR01DK103639 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, ERIC LEO · 2014 to 2016
$890k
Metabolic Regulation of Mucosal InflammationI01BX002182 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI COLGAN, SEAN P · 2014 to 2025
–
BLRD VA I01 BX002182NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK095491NIDDK NIH HHS R01 DK103639NIDDK NIH HHS R01 DK104713NIDDK NIH HHS R37 DK050189
6 · The paper itself

Abstract

Epithelial cells of the mucosa provide a first line of defense to prevent the inappropriate translocation of luminal antigens, and therefore contribute significantly to nonspecific innate immunity. In the gastrointestinal (GI) tract, barrier is provided by multiple components of the mucosa, including mucus production, epithelial junctional complexes, and the production of antimicrobial molecules. In recent years, it is better appreciated that tissue oxygen metabolism is key to homeostasis in the mucosa. The intestine, for example, maintains a low baseline Po

Indexed as

Immunity, InnateAnimalsEpithelial CellsGastrointestinal TractHomeostasisHumansHypoxiaHypoxia-Inducible Factor 1InflammationIntestinal MucosaOxygenSignal TransductionHypoxia-Inducible Factor 1Oxygenautophagybarriercolitisepitheliuminflammationmetabolismmucosa

Identifiers

PMID28705991
PMCPMC5792101
OpenAlexW2735665947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.