Evidence map›Paper›PMID 28705923›Full record

ArticleEuropean journal of endocrinology2017

Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain.

Theodora Kunovac Kallak, Charlotte Hellgren, Alkistis Skalkidou, Lotta Sandelin-Francke, Kumari Ubhayasekhera, Jonas Bergquist, Ove Axelsson, Erika Comasco, Rebecca E Campbell, Inger Sundström Poromaa

Open access · hybridAbstract read
In one paragraph

Article in European journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  6. Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data.Autism research : official journal of the International Society for Autism Research · 2025
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  15. Anthropometric measures do not explain the 2D:4D ratio sexual dimorphism in 7-year-old children.American journal of human biology : the official journal of the Human Biology Council · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Theodora Kunovac KallakDepartments of Women's and Children's Health.
Charlotte HellgrenDepartments of Women's and Children's Health.
Alkistis SkalkidouDepartments of Women's and Children's Health.
Lotta Sandelin-FranckeDepartments of Women's and Children's Health.
Kumari UbhayasekheraChemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden.
Jonas BergquistChemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden.
Ove AxelssonDepartments of Women's and Children's Health.
Erika ComascoDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Rebecca E CampbellCentre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin, New Zealand.
Inger Sundström PoromaaDepartments of Women's and Children's Health.
Uppsala University · SEUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses.

methodsBlood samples from pregnant women (

resultsMultiparity (β = -0.28, WIDER IMPLICATIONS OF THE

findingsYoung maternal age and excessive maternal weight gain may increase the prenatal androgen exposure of female fetuses. Further studies are needed to explore this finding.

Indexed as

Body Mass IndexMaternal AgeAdultAmniotic FluidCohort StudiesDepressionFemaleFetusHumansPregnancyPregnancy ComplicationsSwedenTestosteroneWeight GainTestosterone

Identifiers

PMID28705923
PMCPMC5597951
OpenAlexW2734757017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.