Evidence map›Paper›PMID 28705911›Full record

ArticleCirculation. Heart failure2017

Making the Case for Skeletal Muscle Myopathy and Its Contribution to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction.

Dalane W Kitzman, Mark J Haykowsky, Corey R Tomczak

Registry-linked trialOpen access · bronzeAbstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06130059 (Pilot Study to Evaluate the Efficacy of Low Dose Colchicine), which is not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06130059 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Pilot Study to Evaluate the Efficacy of Low Dose Colchicine (LoDoCo ®) to Improve Exercise Capacity Among Patients With Chronic Stable HFpEF and Systemic Inflammation

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2024 to 2027Enrolled60ConditionsHeart Failure, InflammationArmsLow Dose Colchicine, Placebo
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  15. Metabolic Reprogramming in Heart Failure: From Energy Starvation to Therapeutic Targets.Current treatment options in cardiovascular medicine · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dalane W KitzmanFrom the Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); College of Nursing and Health Innovation, University of Texas at Arlington (M.J.H.); and Integrative Cardiovascular Physiology Lab, College of Kinesiology, University of Saskatchewan, Saskatoon, Canada (C.R.T.). dkitzman@wakehealth.edu.
Mark J HaykowskyFrom the Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); College of Nursing and Health Innovation, University of Texas at Arlington (M.J.H.); and Integrative Cardiovascular Physiology Lab, College of Kinesiology, University of Saskatchewan, Saskatoon, Canada (C.R.T.).
Corey R TomczakFrom the Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); College of Nursing and Health Innovation, University of Texas at Arlington (M.J.H.); and Integrative Cardiovascular Physiology Lab, College of Kinesiology, University of Saskatchewan, Saskatoon, Canada (C.R.T.).
The University of Texas at Arlington · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
SPRINT - HeartR01HL107257 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2011 to 2014
$1.5M
Mechanisms and management of exercise intolerance in older heart failure patients with preserved ejection fraction (HFpEF)R15NR016826 · NINR · UNIVERSITY OF TEXAS ARLINGTON · PI HAYKOWSKY, MARK · 2017 to 2017
$308k
NHLBI NIH HHS R01 HL107257NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NINR NIH HHS R15 NR016826
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Heart FailureStroke VolumeExerciseHumansMuscle, SkeletalMuscular DiseasesEditorialsexercise intoleranceheart failuremagnetic resonance spectroscopymitochondrial functionskeletal muscle

Identifiers

PMID28705911
PMCPMC5546154
OpenAlexW2735650878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.