Evidence map›Paper›PMID 28705884›Full record

ArticleMolecular systems biology2017

Quantitative analysis of protein interaction network dynamics in yeast.

Albi Celaj, Ulrich Schlecht, Justin D Smith, Weihong Xu, Sundari Suresh, Molly Miranda, Ana Maria Aparicio, Michael Proctor, Ronald W Davis, Frederick P Roth and 1 more

Abstract read
In one paragraph

Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Principles of Computation by Competitive Protein Dimerization Networks.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Contextualized Protein-Protein Interactions.Patterns (New York, N.Y.) · 2021
    Article
  14. Molecular networks in Network Medicine: Development and applications.Wiley interdisciplinary reviews. Systems biology and medicine · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Albi CelajDepartments of Molecular Genetics and Computer Science, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5888-772X
Ulrich SchlechtStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Justin D SmithStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-3079-3534
Weihong XuStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-1552-3333
Sundari SureshStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Molly MirandaStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Ana Maria AparicioStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Michael ProctorStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Ronald W DavisStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Frederick P RothDepartments of Molecular Genetics and Computer Science, University of Toronto, Toronto, ON, Canada fritz.roth@utoronto.ca bstonge@stanford.edu.ORCID 0000-0002-6628-649X
Robert P St OngeStanford Genome Technology Center, Stanford University, Palo Alto, CA, USA fritz.roth@utoronto.ca bstonge@stanford.edu.ORCID 0000-0003-1626-3107

Funding

WHOLE YEAST GENOME TRANSCRIPTIONAL AND FUNCTIONAL GENE MAPS--A FEASIBILITY STUDYP01HG000205 · NHGRI · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE, HOWE, ROGER THOMAS · 1990 to 2016
$120.9M
Genomic Analysis of Network Perturbations in Human DiseaseP50HG004233 · NHGRI · DANA-FARBER CANCER INST · PI VIDAL, MARC · 2007 to 2017
$31.6M
Genomic and synthetic biology tools for expressing natural product gene clustersU01GM110706 · NIGMS · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE, STEINMETZ, LARS M · 2014 to 2018
$10.9M
Resource ProjectU41HG001715 · NHGRI · DANA-FARBER CANCER INST · PI HILL, DAVID E. · 2015 to 2017
$4.7M
Identification of Small-Molecule Inhibitors of Protein-Protein InteractionsR21HG005785 · NHGRI · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE · 2010 to 2011
$440k
NHGRI NIH HHS P01 HG000205NHGRI NIH HHS P50 HG004233NHGRI NIH HHS R21 HG005785NHGRI NIH HHS U41 HG001715NIGMS NIH HHS U01 GM110706
6 · The paper itself

Abstract

Many cellular functions are mediated by protein-protein interaction networks, which are environment dependent. However, systematic measurement of interactions in diverse environments is required to better understand the relative importance of different mechanisms underlying network dynamics. To investigate environment-dependent protein complex dynamics, we used a DNA-barcode-based multiplexed protein interaction assay in

Indexed as

Protein Interaction MapsComputer SimulationDNA Barcoding, TaxonomicGene Expression ProfilingModels, BiologicalPeptide HydrolasesProtein Interaction MappingRNA, FungalRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSystems BiologyPeptide HydrolasesRbd2 protein, S cerevisiaeRNA, FungalRNA, MessengerSaccharomyces cerevisiae Proteinsenvironmental responsemRNA expressionnetwork dynamicsprotein complementation assayprotein–protein interactions

Identifiers

PMID28705884
PMCPMC5527849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.