ArticleDiabetes2017
Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning.
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Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
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Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasis.Genes & diseases · 2026Review
- Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective.Cells · 2026Review
- Long-Term Administration of Antioxidant N-Acetyl-L-Cysteine Impacts Beta Cell Oxidative Stress, Insulin Secretion, and Intracellular Signaling Pathways in Aging Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity.Heliyon · 2025Article
- Molecular analysis of long COVID and new-onset diabetes mellitus: pathobiological relationships and current mechanistic views.Frontiers in endocrinology · 2025Review
- Characterization and functional evaluation of goat PDX1 regulatory modules through comparative analysis of conserved interspecies homologs.Scientific reports · 2024Article
- The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus.Nature reviews. Endocrinology · 2024Review
- Intermittent fasting protects β-cell identity and function in a type-2 diabetes model.Metabolism: clinical and experimental · 2024Article
- Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity.Cell metabolism · 2024Article
- Galectin-1 in Pancreatic Ductal Adenocarcinoma: Bridging Tumor Biology, Immune Evasion, and Therapeutic Opportunities.International journal of molecular sciences · 2023Review
- IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation.Physiological reports · 2023Article
- Article
- A low-protein maternal diet during gestation affects the expression of key pancreatic β-cell genes and the methylation status of the regulatory region of theFrontiers in veterinary science · 2023Article
- The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022Review
- SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients.Emerging microbes & infections · 2022Article
- PDX-1: A Promising Therapeutic Target to Reverse Diabetes.Biomolecules · 2022Review
- PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity.Diabetes · 2022Article
- The promising role of hypoxia-resistant insulin-producing cells in ameliorating diabetes mellitusFuture science OA · 2022Article
- Antidiabetic effects of Scrophularia striata ethanolic extract via suppression of Pdx1 and Ins1 expression in pancreatic tissues of diabetic rats.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Jason M SpaethDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Manisha GupteDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Mark PerelisDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Yu-Ping YangProgram in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
Holly CyphertDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Shuangli GuoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Jin-Hua LiuDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Min GuoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Joseph BassDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Mark A MagnusonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.ORCID 0000-0002-8824-6499
Christopher WrightProgram in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
Roland SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN roland.stein@vanderbilt.edu.ORCID 0000-0001-9192-8661
Vanderbilt University · USNorthwestern University · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MCoordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MTRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MIntegration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9MPDX-1,A TRANSCRIPTIONAL ACTIVATOR OF THE INSULIN GENER01DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI BASS, JOSEPH, STEIN, ROLAND W · 1995 to 2020
$6.8MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MGenetic control of pancreatic endocrine cell developmentU01DK089523 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2010 to 2014
$5.3MControl of islet b-specific pdx-1 &mafA transcriptionR56DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI STEIN, ROLAND W · 2005 to 2005
$76kNCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK050203NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R56 DK050203NIDDK NIH HHS U01 DK072473NIDDK NIH HHS U01 DK089523NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637
Abstract
The transcription factor encoded by the
Indexed as
AnimalsCell ProliferationGene Expression RegulationHomeodomain ProteinsInsulin-Secreting CellsMaleMiceMice, KnockoutOxidative PhosphorylationTrans-ActivatorsWeaningHomeodomain Proteinspancreatic and duodenal homeobox 1 proteinTrans-Activators
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.