Evidence map›Paper›PMID 28705835›Full record

ArticleThe Journal of endocrinology2017

Transendothelial movement of adiponectin is restricted by glucocorticoids.

Thanh Q Dang, Nanyoung Yoon, Helen Chasiotis, Emily C Dunford, Qilong Feng, Pingnian He, Michael C Riddell, Scott P Kelly, Gary Sweeney

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Thanh Q DangDepartment of BiologyFaculty of Science York University, Toronto, Canada.
Nanyoung YoonDepartment of BiologyFaculty of Science York University, Toronto, Canada.
Helen ChasiotisDepartment of BiologyFaculty of Science York University, Toronto, Canada.
Emily C DunfordSchool of Kinesiology and Health ScienceFaculty of Health and Muscle Health Research Center, York University, Toronto, Canada.
Qilong FengDepartment of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Pingnian HeDepartment of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Michael C RiddellSchool of Kinesiology and Health ScienceFaculty of Health and Muscle Health Research Center, York University, Toronto, Canada.
Scott P KellyDepartment of BiologyFaculty of Science York University, Toronto, Canada.
Gary SweeneyDepartment of BiologyFaculty of Science York University, Toronto, Canada gsweeney@yorku.ca.
York University · CAPennsylvania State University · US

Funding

CELLULAR MODULATION OF MICROVESSEL PERMEABILITY IN VIVOR01HL056237 · NHLBI · WEST VIRGINIA UNIVERSITY · PI HE, PINGNIAN · 2001 to 2013
$3.1M
Nitric oxide and microvessel permeability in vivoR01HL130363 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2017 to 2020
$1.9M
Microparticles and microvascular dysfunction in diabetesR01DK097391 · NIDDK · WEST VIRGINIA UNIVERSITY · PI HE, PINGNIAN · 2013 to 2016
$1.4M
CELLULAR MODULATION OF MICROVESSEL PERMEABILITY IN VIVOR29HL056237 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI HE, PINGNIAN · 1997 to 2001
$121k
NHLBI NIH HHS R01 HL056237NHLBI NIH HHS R01 HL130363NHLBI NIH HHS R29 HL056237NIDDK NIH HHS R01 DK097391
6 · The paper itself

Abstract

Altered permeability of the endothelial barrier in a variety of tissues has implications both in disease pathogenesis and treatment. Glucocorticoids are potent mediators of endothelial permeability, and this forms the basis for their heavily prescribed use as medications to treat ocular disease. However, the effect of glucocorticoids on endothelial barriers elsewhere in the body is less well studied. Here, we investigated glucocorticoid-mediated changes in endothelial flux of Adiponectin (Ad), a hormone with a critical role in diabetes. First, we used monolayers of endothelial cells

Indexed as

AdiponectinAnimalsDexamethasoneDiabetes Mellitus, ExperimentalElectric ImpedanceEndothelial CellsFemaleGene Expression RegulationHumansMiceMuscle, SkeletalMyosinsRatsRats, Sprague-DawleyRNA, MessengerTight Junction ProteinsAdiponectinDexamethasoneMyosinsRNA, MessengerTight Junction Proteinsadiponectincorticosteronediabetesendothelial transportglucocorticoidshydraulic conductivityparacellulartight junctions

Identifiers

PMID28705835
PMCPMC6231241
OpenAlexW2734961519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.