Evidence map›Paper›PMID 28705832›Full record

ReviewMolecular biology of the cell2017

Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells.

Tomohito Higashi, Ann L Miller

Abstract readReview
In one paragraph

Review in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
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  5. Control of renal calcium permeability via a tight junctional claudin switch.Proceedings of the National Academy of Sciences of the United States of America · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tomohito HigashiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 tohigash@umich.edu annlm@umich.edu.
Ann L MillerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 tohigash@umich.edu annlm@umich.edu.

Funding

Regulation of localized RhoA activity in dividing epithelial cellsR01GM112794 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, ANN LOUISE · 2015 to 2023
$3.0M
NIGMS NIH HHS R01 GM112794
6 · The paper itself

Abstract

Tricellular contacts are the places where three cells meet. In vertebrate epithelial cells, specialized structures called tricellular tight junctions (tTJs) and tricellular adherens junctions (tAJs) have been identified. tTJs are important for the maintenance of barrier function, and disruption of tTJ proteins contributes to familial deafness. tAJs have recently been attracting the attention of mechanobiologists because these sites are hot spots of epithelial tension. Although the molecular components, regulation, and function of tTJs and tAJs, as well as of invertebrate tricellular junctions, are beginning to be characterized, many questions remain. Here we broadly cover what is known about tricellular junctions, propose a new model for tension transmission at tAJs, and discuss key open questions.

Indexed as

Adherens JunctionsAnimalsDeafnessEpithelial CellsHumansMARVEL Domain Containing 2 ProteinMembrane ProteinsProtein TransportTight JunctionsMARVEL Domain Containing 2 ProteinMembrane Proteins

Identifiers

PMID28705832
PMCPMC5509417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.