Evidence map›Paper›PMID 28705817›Full record

ArticleAJNR. American journal of neuroradiology2017

Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New "Leave Me Alone" Lesion with a Characteristic Imaging Pattern.

R H Nunes, C C Hsu, A J da Rocha, L L F do Amaral, L F S Godoy, T W Watkins, V H Marussi, M Warmuth-Metz, H C Alves, F G Goncalves and 2 more

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Multinodular and vacuolating posterior fossa lesions of unknown significance: a long-term observational study and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Observational
  15. Article
  16. Imaging of pediatric glioneuronal and neuronal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

R H NunesFrom the Division of Neuroradiology (R.H.N., A.J.d.R., L.L.F.d.A., H.C.A.), Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil renatohn@hotmail.com.ORCID http://orcid.org/0000-0002-2483-964X
C C HsuDepartment of Medical Imaging (C.C.H., T.W.W.), Princess Alexandra Hospital, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-0803-593X
A J da RochaFrom the Division of Neuroradiology (R.H.N., A.J.d.R., L.L.F.d.A., H.C.A.), Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0003-2591-9171
L L F do AmaralFrom the Division of Neuroradiology (R.H.N., A.J.d.R., L.L.F.d.A., H.C.A.), Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0003-2944-9947
L F S GodoyDepartment of Radiology (L.F.S.G.), Hospital Sirio Libanes, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-6918-6865
T W WatkinsDepartment of Medical Imaging (C.C.H., T.W.W.), Princess Alexandra Hospital, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-8027-2118
V H MarussiDivision of Neuroradiology (L.L.F.d.A., V.H.M.), Medimagem, Hospital da Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-0333-0342
M Warmuth-MetzDepartment of Neuroradiology (M.W.-M.), University Hospital Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3544-319X
H C AlvesFrom the Division of Neuroradiology (R.H.N., A.J.d.R., L.L.F.d.A., H.C.A.), Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-4693-8278
F G GoncalvesDepartment of Radiology (F.G.G.), Children's Hospital of Brasilia, Brasilia, Brazil.ORCID http://orcid.org/0000-0002-8889-9879
B K Kleinschmidt-DeMastersDepartment of Pathology (B.K.K.-D.), University of Colorado, Aurora, Colorado.ORCID http://orcid.org/0000-0002-4471-1678
A G OsbornDepartment of Radiology (A.G.O.), University of Utah, Salt Lake City, Utah.ORCID http://orcid.org/0000-0002-5221-8306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR. Only 4 of our cases are biopsy-proven because most were asymptomatic and incidentally discovered. The remaining were followed for a minimum of 24 months (mean, 3 years) without interval change. We demonstrate that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm.

Indexed as

AdultBrain NeoplasmsCerebrumFemaleGanglioneuromaHumansMagnetic Resonance ImagingMaleMiddle AgedNeuronsWhite Matter

Identifiers

PMID28705817
PMCPMC7963604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.