Evidence map›Paper›PMID 28705497›Full record

ArticleNeuroImage2017

Quicksilver: Fast predictive image registration - A deep learning approach.

Xiao Yang, Roland Kwitt, Martin Styner, Marc Niethammer

Abstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. AI in Proton Therapy Treatment Planning: A Narrative Review.International journal of particle therapy · 2026
    Article
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  7. On the accuracy of image registration in portable low-field 3D brain MRI.bioRxiv : the preprint server for biology · 2026
    Article
  8. Unified Brain Surface and Volume Registration.... International Conference on Learning Representations · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. [AI-based applications in medical image computing].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
    Review
  14. Uncertainty Quantification in Image-based 2D/3D Registration and Its Relationship with Accuracy.International journal of computer assisted radiology and surgery · 2025
    Article
  15. CARL: A Framework for Equivariant Image Registration.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  16. Unraveling Normal Anatomy via Fluid-Driven Anomaly Randomization.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  17. MultiMorph: On-demand Atlas Construction.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  18. Article
  19. Article
  20. Article

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao YangUniversity of North Carolina at Chapel Hill, Chapel Hill, USA. Electronic address: xy@cs.unc.edu.
Roland KwittDepartment of Computer Science, University of Salzburg, Austria.
Martin StynerUniversity of North Carolina at Chapel Hill, Chapel Hill, USA; Department of Psychiatry, UNC, Chapel Hill, USA.
Marc NiethammerUniversity of North Carolina at Chapel Hill, Chapel Hill, USA; Biomedical Research Imaging Center (BRIC), Chapel Hill, USA.

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
Multimodality Image-Based Assessment System for Traumatic Brain InjuryR44NS081792 · NINDS · KITWARE, INC. · PI AYLWARD, STEPHEN R, NIETHAMMER, MARC · 2015 to 2016
$1.3M
NICHD NIH HHS R01 HD055741NINDS NIH HHS R44 NS081792
6 · The paper itself

Abstract

This paper introduces Quicksilver, a fast deformable image registration method. Quicksilver registration for image-pairs works by patch-wise prediction of a deformation model based directly on image appearance. A deep encoder-decoder network is used as the prediction model. While the prediction strategy is general, we focus on predictions for the Large Deformation Diffeomorphic Metric Mapping (LDDMM) model. Specifically, we predict the momentum-parameterization of LDDMM, which facilitates a patch-wise prediction strategy while maintaining the theoretical properties of LDDMM, such as guaranteed diffeomorphic mappings for sufficiently strong regularization. We also provide a probabilistic version of our prediction network which can be sampled during the testing time to calculate uncertainties in the predicted deformations. Finally, we introduce a new correction network which greatly increases the prediction accuracy of an already existing prediction network. We show experimental results for uni-modal atlas-to-image as well as uni-/multi-modal image-to-image registrations. These experiments demonstrate that our method accurately predicts registrations obtained by numerical optimization, is very fast, achieves state-of-the-art registration results on four standard validation datasets, and can jointly learn an image similarity measure. Quicksilver is freely available as an open-source software.

Indexed as

AlgorithmsBrainBrain MappingHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMachine LearningPattern Recognition, AutomatedBrain imagingDeep learningImage registration

Identifiers

PMID28705497
PMCPMC6036629

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.