ArticleNeurobiology of aging2017
Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Observational
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Association of 8-hydroxy-2'-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study.BMC geriatrics · 2024Article
- Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study.Immunologic research · 2024Article
- Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- Biological Age Acceleration and Motoric Cognitive Risk Syndrome.Annals of neurology · 2023Article
- Sarcopenia and motoric cognitive risk syndrome: a moderated mediation model.BMC geriatrics · 2022Article
- Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis.Frontiers in aging neuroscience · 2022Article
- Motoric cognitive risk syndrome in people with multiple sclerosis: prevalence and correlations with disease-related factors.Therapeutic advances in neurological disorders · 2022Article
- Cortical Thickness, Volume, and Surface Area in the Motoric Cognitive Risk Syndrome.Journal of Alzheimer's disease : JAD · 2021Article
- Motoric Cognitive Risk Syndrome: Symptoms, Pathology, Diagnosis, and Recovery.Frontiers in aging neuroscience · 2021Review
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
- Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations.Annals of geriatric medicine and research · 2020Review
- Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study.Neurology · 2019Article
- An Immunological Perspective to Non-syndromic Sensorineural Hearing Loss.Frontiers in immunology · 2019Article
- Frailty and Risk of Incident Motoric Cognitive Risk Syndrome.Journal of Alzheimer's disease : JAD · 2019Article
- Association of cardiometabolic multimorbidity with motoric cognitive risk syndrome in older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Motoric cognitive risk (MCR) syndrome is a newly described predementia syndrome characterized by the presence of cognitive complaints and slow gait, which is associated with increased risk of conversion to dementia. The underlying biological mechanisms for MCR have not yet been established. Neuroinflammation mediated through cytokines plays a pivotal role in the pathogenesis of dementia. Hence, our objective was to prospectively examine whether variations in cytokine genes (CRP, IFNG, IL1A, IL1B, IL4, IL6, IL10, IL18, TNF, and IL12A) play a role in MCR incidence in 530 community-dwelling Ashkenazi Jewish adults aged 65 years and older without MCR or dementia at baseline enrolled in the LonGenity study. Over a median follow-up of 2.99 years, 70 participants developed MCR. Single nucleotide polymorphisms (SNPs) in the transcriptional regulatory regions of cytokine IL10, rs1800896 (hazard ratio adjusted for age, gender, and education, aHR: 1.667; 95% CI: 1.198-2.321) and rs3024498 (aHR: 1.926; 95% CI: 1.315-2.822), were associated with incident MCR. Functional analysis using in silico approaches indicated associated SNP rs3024498 "C" allele being the local expression quantitative trait locus. Associated alleles of both the SNPs, rs1800896 and rs3024498, were implicated with overexpression of IL10 gene. None of the variants in the neuroinflammatory pathway studied were associated with incident mild cognitive impairment syndrome. These observations support a role for the IL10 gene in dementia pathogenesis by increasing risk of developing MCR in older adults.
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