ReviewDeutsches Arzteblatt international2017
The Diagnosis and Treatment of Behavioral Disorders in Dementia.
Review in Deutsches Arzteblatt international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Developing an ontology of non-pharmacological treatment for emotional and mood disturbances in dementia.Scientific reports · 2024Article
- [Deprescribing of antipsychotic drugs for dementia : Recommendations for action on dose reduction and discontinuation attempts].Der Nervenarzt · 2022Article
- Personalized Management and Treatment of Alzheimer's Disease.Life (Basel, Switzerland) · 2022Review
- Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization and Development.Methods in molecular biology (Clifton, N.J.) · 2022Article
- [Challenging behavior in longterm care].MMW Fortschritte der Medizin · 2021Article
- Relation among Caregivers' Burden, Abuse and Behavioural Disorder in People with Dementia.International journal of environmental research and public health · 2021Article
- Singing and music making: physiological responses across early to later stages of dementia.Wellcome open research · 2021Article
- Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States.Journal of Alzheimer's disease : JAD · 2021Article
- Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer's Dementia Are Frequently Below the Recommended Levels.Frontiers in pharmacology · 2020Article
- Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy.Deutsches Arzteblatt international · 2019Review
- [Challenging behavior and pain in dementia : Experiences of nursing staff in an acute care hospital].Schmerz (Berlin, Germany) · 2019Article
- The Prevalence of Dementia and Cognitive Impairment in Hospitals.Deutsches Arzteblatt international · 2018Article
- Dementia Care at End of Life: Current Approaches.Current psychiatry reports · 2018Review
- [Provision of palliative care for people with advanced dementia].Der Nervenarzt · 2018Review
- Paying Attention to Electrolytes.Deutsches Arzteblatt international · 2017Article
- In Reply.Deutsches Arzteblatt international · 2017Article
- Additional Comments.Deutsches Arzteblatt international · 2017Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehavioral disorders such as aggressiveness, agitation, delusions, disinhibition, affect lability, and apathy arise in more than 90% of patients with dementia. Behavioral disorders are a major challenge and the greatest stress factor in everyday life for nursing personnel and for family members caring for the patient.
methodsThis review is based on relevant publications retrieved by a selective literature search in the PubMed, Cochrane Library, and German S3 guideline databases with the search terms "behavioral disorders," "non-cognitive disorders," and "challenging behavior," in conjunction with "dementia" and "behavioral and psychological symptoms of dementia."
resultsBehavioral disorders regularly accompany dementing illness and have identifiable and treatable somatic and environment-related causes. They should be treated symptomatically, both with non-pharmacological measures and with drugs. Memory therapy (d = 0.47), ergotherapy (d = 0.72), music therapy (d = 0.62), and physical exercise (d = 0.68) are effective, as are antidementia drugs (galantamine: p = 0.04, donepezil: p = 0.01, rivastigmine: p = 0.02, memantine: p = 0.004). Risperidone is the drug of choice to combat agitation and aggressiveness (d = 0.33) as well as dementia and hallucinations (d = 0.5). Citalopram can be recommended for the treatment of depression in patients with dementia (p = 0.05).
conclusionBecause of an improved evidence base, the latest version of the German S3 guideline on the diagnosis and treatment of dementia places greater emphasis on non-pharmacological treatments for behavioral disorders in dementia than it did in the past. The global efficacy of such treatments against behavioral disorders is well documented. Nonetheless, because of the heterogeneity of interventions and varying standards of assessment, the evidence for the utility of certain specific methods in the treatment of specific behavioral disorders is still limited. More research is needed in this area.
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