Evidence map›Paper›PMID 28705245›Full record

ArticleParasites & vectors2017

Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity.

Elizabeth K K Glennon, Brandi K Torrevillas, Shannon F Morrissey, Jadrian M Ejercito, Shirley Luckhart

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Elizabeth K K GlennonDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, CA, USA.
Brandi K TorrevillasDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, CA, USA.
Shannon F MorrisseyDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, CA, USA.
Jadrian M EjercitoDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, CA, USA.
Shirley LuckhartDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, CA, USA. sluckhart@uidaho.edu.
Infectious Disease Research Institute · USUniversity of California, Riverside · USUniversity of Idaho · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbscisic acid (ABA) is naturally present in mammalian blood and circulating levels can be increased by oral supplementation. We showed previously that oral ABA supplementation in a mouse model of Plasmodium yoelii 17XNL infection reduced parasitemia and gametocytemia, spleen and liver pathology, and parasite transmission to the mosquito Anopheles stephensi fed on these mice. Treatment of cultured Plasmodium falciparum with ABA at levels detected in our model had no effects on asexual growth or gametocyte formation in vitro. However, ABA treatment of cultured P. falciparum immediately prior to mosquito feeding significantly reduced oocyst development in A. stephensi via ABA-dependent synthesis of nitric oxide (NO) in the mosquito midgut.

resultsHere we describe the mechanisms of effects of ABA on mosquito physiology, which are dependent on phosphorylation of TGF-β-activated kinase 1 (TAK1) and associated with changes in homeostatic gene expression and activity of kinases that are central to metabolic regulation in the midgut epithelium. Collectively, the timing of these effects suggests a transient physiological shift that enhances NF-κB-dependent innate immunity without significantly altering mosquito lifespan or fecundity.

conclusionsABA is a highly conserved regulator of immune and metabolic homeostasis within the malaria vector A. stephensi with potential as a transmission-blocking supplemental treatment.

Indexed as

Signal TransductionAbscisic AcidAnimalsAnophelesCell SurvivalFertilityImmunity, InnateLongevityMiceNF-kappa BPlasmodium falciparumAbscisic AcidNF-kappa BAbscisic acidAnopheles stephensiInnate immunityLifespanMalariaNitric oxidePlasmodium falciparumTAK1Transmission

Identifiers

PMID28705245
PMCPMC5508651
OpenAlexW2735499982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.