ArticleAJR. American journal of roentgenology2017
Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver.
Article in AJR. American journal of roentgenology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 101 citations in OpenAlex.
- Head-to-head comparison among FAST, MAST, and multiparametric MRI-based new score in diagnosing at-risk MASH.European radiology · 2025Trial
- Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: the ATTIS study, a randomized controlled trial.The American journal of clinical nutrition · 2020Trial
- Inter-reader agreement of magnetic resonance imaging proton density fat fraction and its longitudinal change in a clinical trial of adults with nonalcoholic steatohepatitis.Abdominal radiology (New York) · 2019Trial
- Reproducibility of ROI methods and reliability of conventional versus chemical shift-encoded MRI for hepatic fat and iron quantification.Abdominal radiology (New York) · 2026Article
- Neoadjuvant Oxaliplatin and Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma: CT Features of Chemotherapy-Associated Liver Injury and Postoperative Complications.Annals of surgical oncology · 2026Article
- Hepatic Fat Quantification Using Beta Distribution and a Probabilistic Neural Network in a Prepubertal Male Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Highly Reproducible, Vendor-Agnostic, Motion-Insensitive Liver PDFF Mapping at 0.55T, 1.5T, and 3T.Magnetic resonance in medicine · 2026Article
- Fraction Conversion Models Based on Ultrasound Attenuation Coefficient for Assessing Liver Steatosis.Diagnostics (Basel, Switzerland) · 2026Article
- Comparison of Manual Multi-ROI, Single-Location, and Volumetric Fat Fraction Measurements for Hepatic Steatosis Using MRI.Diagnostics (Basel, Switzerland) · 2026Article
- Fat-Corrected Non-Gaussian Diffusion MRI for Liver Fibrosis Assessment in Metabolic Dysfunction-Associated Steatotic Liver Disease.Journal of magnetic resonance imaging : JMRI · 2026Article
- Proton density fat fraction for diagnosis of metabolic dysfunction-associated steatotic liver disease.Hepatology (Baltimore, Md.) · 2026Article
- Comparison of ultrasound-derived fat fraction and hepatorenal index for quantitative detection of hepatic steatosis: a multicenter MRI-PDFF-referenced study.Frontiers in nutrition · 2026Article
- Optimized motion-insensitive PDFF mapping of the liver.Magnetic resonance in medicine · 2026Article
- Motion-Insensitive Flip Angle Modulated Liver Proton Density Fat-Fraction and R2* Mapping During Free-Breathing MRI in a Clinical Setting.Journal of magnetic resonance imaging : JMRI · 2025Observational
- T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025Review
- Reproducibility of liver ADC measurements using first moment optimized diffusion imaging.Magnetic resonance in medicine · 2025Article
- Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome.Scientific reports · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Article
- Gamma-glutamyl transferase: A potential biomarker for pancreas steatosis in patients with concurrent obesity, insulin resistance and metabolic dysfunction-associated steatotic liver disease.Clinical obesity · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to evaluate the reproducibility (interreviewer agreement) and repeatability (intrareviewer agreement) of ROI sampling strategies to measure chemical shift-encoded (CSE) MRI-based liver proton density fat fraction (PDFF) and R2* (1 / T2*). A secondary purpose was to standardize ROI-based liver PDFF and R2* measurements by providing a compromise between measurement reproducibility and repeatability and time burden for image analysts. MATERIALS AND
methodsCSE data from two cohorts were retrospectively analyzed. Cohort A included 53 patients referred for abdominal MRI and healthy subjects recruited for a comparison study of CT and MRI. Cohort B included 37 patients with suspected liver iron overload. Three reviewers measured liver PDFF and R2* using previously reported ROI sampling strategies. Inter- and intrareviewer agreement of liver PDFF and R2* were evaluated using Bland-Altman analysis.
resultsAveraging largest-fit ROIs over the nine Couinaud segments resulted in the narrowest limits of agreement (LOA) for liver PDFF and R2* measurements in both cohorts. For PDFF, interreviewer agreement had mean LOA of ± 0.8% for cohort A and ± 1.7% for cohort B. Intrareviewer agreement was ± 0.5% for cohort A and ± 0.9% for cohort B. For R2* interre-viewer agreement had mean LOA of ± 3.0 s
conclusionFor improved reproducibility and repeatability of liver PDFF and R2* measurements, clinicians and researchers should sample as much area of the liver as possible using multiple large ROIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.