Evidence map›Paper›PMID 28704967›Full record

ArticleInternational journal of molecular sciences2017

Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair.

Jaime Matta, Carmen Ortiz, Jarline Encarnación, Julie Dutil, Erick Suárez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. C1orf112 promotes breast cancer growth by modulating the cell cycle.Frontiers in bioengineering and biotechnology · 2026
    Article
  4. Article
  5. The Unique Spectrum ofThe application of clinical genetics · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Drug Combinations in Breast Cancer Therapy.Pharmaceutical nanotechnology · 2019
    Review
  11. Molecular Pathways of Estrogen Receptor Action.International journal of molecular sciences · 2018
    Article
  12. Clinical risk analysis of non-visualized sentinel lymph node in breast cancer.Cancer biomarkers : section A of Disease markers · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jaime MattaDepartment of Basic Sciences, Divisions of Pharmacology, Toxicology, Biochemistry and Cancer Biology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce 00716-2348, Puerto Rico. jmatta@psm.edu.
Carmen OrtizDepartment of Basic Sciences, Divisions of Pharmacology, Toxicology, Biochemistry and Cancer Biology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce 00716-2348, Puerto Rico. carmenortiz@psm.edu.
Jarline EncarnaciónDepartment of Basic Sciences, Divisions of Pharmacology, Toxicology, Biochemistry and Cancer Biology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce 00716-2348, Puerto Rico. jencarnacion@psm.edu.
Julie DutilDepartment of Basic Sciences, Divisions of Pharmacology, Toxicology, Biochemistry and Cancer Biology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce 00716-2348, Puerto Rico. jdutil@psm.edu.
Erick SuárezDepartment of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan 00936-5067, Puerto Rico. erick.suarez@upr.edu.

Funding

Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KENNETH Lynn WRIGHT · 2012 to 2026
$23.1M
RISE Option III: Ponce School of Medicine MBRS-RISE ProgramR25GM082406 · NIGMS · PONCE SCHOOL OF MEDICINE · PI APPLEYARD, CAROLINE B · 2008 to 2021
$9.5M
FUNCTIONAL ANALYSIS OF BRCA1 MUTANTSR01CA092309 · NCI · STRANG CANCER PREVENTION CENTER · PI MONTEIRO, ALVARO N · 2002 to 2006
$1.3M
NCI NIH HHS R01 CA092309NCI NIH HHS U54 CA163068NIGMS NIH HHS R25 GM082406
6 · The paper itself

Abstract

Breast cancer (BC) is a heterogeneous disease which many studies have classified in at least four molecular subtypes: Luminal A, Luminal B, HER2-Enriched, and Basal-like (including triple-negative breast cancer, TNBC). These subtypes provide information to stratify patients for better prognostic predictions and treatment selection. Individuals vary in their sensitivities to carcinogens due to differences in their DNA repair capacity (DRC) levels. Although our previous case-control study established low DRC (in terms of NER pathway) as a BC risk factor, we aim to study this effect among the molecular subtypes. Therefore, the objectives of this study include investigating whether DRC varies among molecular subtypes and testing any association regarding DRC. This study comprised 267 recently diagnosed women with BC (cases) and 682 without BC (controls). Our results show a substantial variability in DRC among the molecular subtypes, with TNBC cases (

Indexed as

AgedCase-Control StudiesDNA RepairFemaleHumansMaleMiddle AgedPrecision MedicineRegression AnalysisRisk FactorsTriple Negative Breast Neoplasmsbreast cancerDNA repair capacitymolecular subtypesmultinomial regression analysisphenotypic variabilityprecision medicine

Identifiers

PMID28704967
PMCPMC5535995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.