Evidence map›Paper›PMID 28704658›Full record

ArticleCell host & microbe2017

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.

Elena Zaitseva, Eugene Zaitsev, Kamran Melikov, Anush Arakelyan, Mariana Marin, Rafael Villasmil, Leonid B Margolis, Gregory B Melikyan, Leonid V Chernomordik

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. A Brief Introduction into the Biological Phenomenon of Cell-Cell Fusion.Advances in experimental medicine and biology · 2026
    Review
  8. Article
  9. Article
  10. A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Phosphatidylserine externalization as immune checkpoint in cancer.Pflugers Archiv : European journal of physiology · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elena ZaitsevaSection on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Eugene ZaitsevSection on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Kamran MelikovSection on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Anush ArakelyanSection on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Mariana MarinDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Rafael VillasmilFlow Cytometry Core, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Leonid B MargolisSection on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Gregory B MelikyanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Leonid V ChernomordikSection on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: chernoml@mail.nih.gov.
National Institutes of Health · USEmory University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Protein-mediated membrane remodelingZIAHD001501 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI CHERNOMORDIK, LEONID V. · 2009 to 2025
$30.7M
Cell Interactions in Three Dimensional Tissue CultureZIAHD001416 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARGOLIS, LEONID B. · 2009 to 2017
$15.7M
BIOPHYSICS OF PROTEIN-MEDIATED MEMBRANE FUSIONR01GM054787 · NIGMS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI MELIKIAN, GREGORY B · 2000 to 2018
$6.5M
TISSUE IMAGING IN CELL BIOLOGYZ01HD001416 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARGOLIS, LEONID B. · 1993 to 2008
$2.7M
ROLE OF LIPIDS IN MEMBRANE REARRANGEMENTSZ01HD001501 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI CHERNOMORDIK, LEONID V. · 1992 to 2008
$2.4M
Intramural NIH HHS Z01 HD001416Intramural NIH HHS Z01 HD001501Intramural NIH HHS Z99 HD999999NIGMS NIH HHS R01 GM054787
6 · The paper itself

Abstract

HIV-1 entry into host cells starts with interactions between the viral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors. Previous work has suggested that efficient HIV entry also depends on intracellular signaling, but this remains controversial. Here we report that formation of the pre-fusion Env-CD4-coreceptor complexes triggers non-apoptotic cell surface exposure of the membrane lipid phosphatidylserine (PS). HIV-1-induced PS redistribution depends on Ca

Indexed as

Virus InternalizationAmidesAnoctaminsAntibodies, MonoclonalBenzylaminesCalciumCD4 AntigensCell LineCell MembraneCyclamsHEK293 CellsHeLa CellsHeterocyclic CompoundsHIV-1HIV InfectionsHost-Pathogen InteractionsAmidesANO6 protein, humanAnoctaminsAntibodies, MonoclonalBenzylaminesCalciumCCR5 protein, humanCD4 AntigensCXCR4 protein, humanCyclamsHeterocyclic CompoundsPhosphatidylserinesPhospholipid Transfer ProteinsplerixaforQuaternary Ammonium CompoundsReceptors, CCR5Receptors, CXCR4TAK 779Viral Envelope Proteinscell activationcell signalinggp120-CD4-coreceptorhemifusionHIV entrylipid scramblasemembrane fusionphosphatidylserine exposureTMEM16F activityviral entry

Identifiers

PMID28704658
PMCPMC5558241
OpenAlexW2736051115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.