Evidence map›Paper›PMID 28704652›Full record

ArticleCell host & microbe2017

Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections.

Jonathan Chow, Zsuzsa Márka, Imre Bartos, Szabolcs Márka, Jonathan C Kagan

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. STING-dependent translation inhibition restricts RNA virus replication.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jonathan ChowHarvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.
Zsuzsa MárkaDepartment of Physics, Columbia University, New York, NY, USA.
Imre BartosDepartment of Physics, Columbia University, New York, NY, USA.
Szabolcs MárkaDepartment of Physics, Columbia University, New York, NY, USA.
Jonathan C KaganHarvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.
Columbia University · USBoston Children's Hospital · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
Initiation and Regulation of Antiviral Innate ImmunityR01AI093589 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2011 to 2020
$4.4M
Defining the pathways activated by Toll-like Receptors to stimulate immunityR37AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2021 to 2026
$3.3M
Characterization of the myddosome, a protein complex that controls TLR signalingR01AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2017 to 2020
$1.8M
Initiation and Regulation of Antiviral Innate ImmunityR56AI093589 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2021 to 2021
$531k
NIAID NIH HHS R01 AI093589NIAID NIH HHS R01 AI116550NIAID NIH HHS R37 AI116550NIAID NIH HHS R56 AI093589NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Asymptomatic infections often proceed undetected, yet can still prime the host to be sensitive to secondary environmental stress. While the mechanisms underlying disease caused by asymptomatic infections are unknown, it is believed that productive pathogen replication is required. We report that the environmental stress of carbon dioxide (CO

Indexed as

EnvironmentStress, PhysiologicalVirus DiseasesAnimalsAnimals, Genetically ModifiedAnophelesAntiviral AgentsBehavior, AnimalCarbon DioxideDrosophila melanogasterGlycoproteinsHydrogen-Ion ConcentrationImmunity, InnateNeurogliaNeuronsRNA InterferenceAntiviral AgentsCarbon DioxideGlycoproteinsViral Proteinscarbon dioxideCO2Drosophilaglial cellinnate immunityneuroimmunologyneuronsyncytiavesicular stomatitis virusVSV

Identifiers

PMID28704652
PMCPMC5560172
OpenAlexW2734523584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.