Evidence map›Paper›PMID 28704644›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2017

Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas.

Shanshan Jiang, Charles G Eberhart, Yi Zhang, Hye-Young Heo, Zhibo Wen, Lindsay Blair, Huamin Qin, Michael Lim, Alfredo Quinones-Hinojosa, Jon D Weingart and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Shanshan JiangDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA; Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Charles G EberhartDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Yi ZhangDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Hye-Young HeoDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Zhibo WenDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lindsay BlairDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Huamin QinDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Michael LimDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Alfredo Quinones-HinojosaDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Jon D WeingartDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Peter B BarkerDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Martin G PomperDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
John LaterraDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Peter C M van ZijlDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jaishri O BlakeleyDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: jblakel3@jhmi.edu.
Jinyuan ZhouDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: jzhou@mri.jhu.edu.
Johns Hopkins University · USKennedy Krieger Institute · USSouthern Medical University · CN

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MORI, SUSUMU · 2012 to 2020
$13.1M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI WILSON, MARY A · 2014 to 2019
$7.9M
Novel Approaches for CEST Labeling, Detection, Quantification and TranslationR01EB015032 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2011 to 2019
$3.9M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7TR01EB009731 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2009 to 2016
$2.9M
Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationR01NS070024 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2010 to 2014
$2.4M
Academic-Industrial Partnership to Develop Clinical Brain Cancer ImagingR01CA166171 · NCI · JOHNS HOPKINS UNIVERSITY · PI VAN ZIJL, PETER CM, ZHOU, JINYUAN · 2013 to 2017
$2.4M
US-China Collaborative Research on Stroke ImagingR01NS083435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2013 to 2015
$588k
NCI NIH HHS R01 CA166171NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB009731NIBIB NIH HHS R01 EB015032NICHD NIH HHS U54 HD079123NINDS NIH HHS R01 NS070024NINDS NIH HHS R01 NS083435
6 · The paper itself

Abstract

purposePathological assessment using World Health Organization (WHO) criteria is the gold standard for diagnosis of gliomas. However, the accuracy of diagnosis is limited by tissue sampling, particularly for infiltrating, heterogeneous tumours. We assessed the accuracy of amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI)-guided tissue sampling to identify regions of high-grade glioma via radiographic-histopathologic correlation in patients with newly suspected glioma. PATIENTS AND

methodsTwenty-four patients with previously undiagnosed gliomas underwent a volumetric APTw MRI prior to their first neurosurgical procedure. A total of 70 specimens were collected via APTw image-directed stereotactic biopsy. Cellularity, necrosis, proliferation and glioma WHO grade were analysed for all specimens and correlated with corresponding APTw signal intensities.

resultsThirty-three specimens displayed grade-II pathology, 14 grade-III, 15 grade-IV, and eight specimens revealed only peritumoural oedema. Multiple glioma grades were found within a single lesion in six patients. APTw signal intensities of the biopsied sites and the maximum APTw values across all biopsied sites in each patient were significantly higher for high-grade versus low-grade specimens. APTw signal intensities were significantly positively correlated with cellularity (R = 0.757) and proliferation (R = 0.538). Multiple linear regression analysis showed that tumour cellularity and proliferation index were the best predictors of APTw signal intensities.

conclusionAPTw imaging identified tumour areas of higher cellularity and proliferation, allowing identification of high-grade regions within heterogeneous gliomas. APTw imaging can be readily translated for more widespread use and can assist diagnostic neurosurgical procedures by increasing the accuracy of tumour sampling in patients with infiltrating gliomas.

Indexed as

Stereotaxic TechniquesAdultAgedAmidesBiopsyBrain NeoplasmsFemaleGliomaHumansImaging, Three-DimensionalMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProspective StudiesProtonsAmidesProtonsAmide proton transfer-weighted imagingGliomaHistopathologic validationImage-guided biopsyImaging biomarker

Identifiers

PMID28704644
PMCPMC5572540
OpenAlexW2735340448

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.