ArticlePloS one2017
Assessment of gut microbiota populations in lean and obese Zucker rats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- AdultBiomolecules · 2026Article
- Sleeve Gastrectomy Protects Against Hypertension in Rats due to Changes in the Gut Microbiome.The Journal of surgical research · 2024Article
- An ethically guided preclinical device for phenotyping HAnimal models and experimental medicine · 2024Article
- Spirulina (Nutrients · 2024Article
- Long access heroin self-administration significantly alters gut microbiome composition and structure.Frontiers in psychiatry · 2024Article
- Obesogenic Diet Cycling Produces Graded Effects on Cognition and Microbiota Composition in Rats.Molecular nutrition & food research · 2023Article
- Metabolomic Study of Aging inMetabolites · 2023Article
- Potential Roles of the Gut Microbiota in Pancreatic Carcinogenesis and Therapeutics.Frontiers in cellular and infection microbiology · 2022Review
- Changes in Metabolic Regulation and the Microbiota Composition after Supplementation with Different Fatty Acids in db/db Mice.International journal of food science · 2022Article
- Short-Term Metformin Treatment EnrichesFrontiers in microbiology · 2022Article
- The Influence of Diet and Sex on the Gut Microbiota of Lean and Obese JCR:LA-Microorganisms · 2021Article
- Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.Pharmacological reviews · 2021Review
- Article
- Integrative Longitudinal Analysis of Metabolic Phenotype and Microbiota Changes During the Development of Obesity.Frontiers in cellular and infection microbiology · 2021Article
- Effects of exercise frequency on the gut microbiota in elderly individuals.MicrobiologyOpen · 2020Article
- Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post-bariatric surgery patients.Experimental and therapeutic medicine · 2019Article
- Beneficial Effect of Virgin Coconut Oil on Alloxan-Induced Diabetes and Microbiota Composition in Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2018Article
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model.American journal of physiology. Endocrinology and metabolism · 2018Article
- 16S rRNA Sequencing Reveals Relationship Between Potent Cellulolytic Genera and Feed Efficiency in the Rumen of Bulls.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has been on the rise in the US and worldwide for the last several decades. Obesity has been associated with chronic disease development, such as certain types of cancer, type 2 diabetes, cardiovascular disease, and liver diseases. Previously, we reported that obesity promotes DMBA-induced mammary tumor development using the obese Zucker rat model. The intestinal microbiota is composed of a diverse population of obligate and facultative anaerobic microorganisms, and these organisms carry out a broad range of metabolic activities. Obesity has been linked to changes in the intestinal microbiota, but the composition of the bacterial populations in lean and obese Zucker rats has not been carefully studied. Therefore, the objective of this study was to determine the effects of obesity on the gut microbiota in this model. Lean and obese female Zucker rats (n = 16) were fed an AIN-93G-like diet for 8 weeks. Rats were weighed twice weekly, and fecal samples were collected at the beginning and end of the experiment. 16S rRNA gene sequencing was used to evaluate the composition of the fecal bacterial populations. At the outset of the study, the lean rats exhibited much lower ratios of the Firmicutes to Bacteroidetes phyla than the obese rats, but after 60 days, this ratio in the lean rats exceeded that of the obese. This shift was associated with reductions in the Bacteroidaceae, S24-7 and Paraprevotellaceae families in the lean rats. Obese rats also showed increased levels of the genus Akkermansia at day 60. PCoA plots of beta diversity showed clustering of the different test groups, indicating clear differences in intestinal microbiota populations associated with both the time point of the study and the lean or obese status in the Zucker rat model for obesity.
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