ArticlePloS one2017
A consensus layer V pyramidal neuron can sustain interpulse-interval coding.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Communication consumes 35 times more energy than computation in the human cortex, but both costs are needed to predict synapse number.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Estimating the Parameters of Fitzhugh-Nagumo Neurons from Neural Spiking Data.Brain sciences · 2019Article
- Cortical reliability amid noise and chaos.Nature communications · 2019Article
- Linearization of excitatory synaptic integration at no extra cost.Journal of computational neuroscience · 2018Article
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Authors and funding
2 authors.
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Abstract
In terms of a single neuron's long-distance communication, interpulse intervals (IPIs) are an attractive alternative to rate and binary codes. As a proxy for an IPI, a neuron's time-to-spike can be found in the biophysical and experimental intracellular literature. Using the current, consensus layer V pyramidal neuron, the present study examines the feasibility of IPI-coding and examines the noise sources that limit the information rate of such an encoding. In descending order of importance, the noise sources are (i) synaptic variability, (ii) sodium channel shot-noise, followed by (iii) thermal noise. The biophysical simulations allow the calculation of mutual information, which is about 3.0 bits/spike. More importantly, while, by any conventional definition, the biophysical model is highly nonlinear, the underlying function that relates input intensity to the defined output variable is linear. When one assumes the perspective of a neuron coding via first hitting-time, this result justifies a pervasive and simplifying assumption of computational modelers-that a class of cortical neurons can be treated as linearly additive, computational devices.
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