ArticlePLoS genetics2017
Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Response to geographic song variation predicts differential gene expression in the blood of a songbird.iScience · 2026Article
- Tracking Cell Movement in Two-Dimensional, Fragmented Microcosms Reveals Dispersal Syndromes and Strategies inEcology and evolution · 2026Article
- Predator Communities With Invasive Pike Are Associated With Changes in Parental Care and Brain Gene Expression in Wild Alaskan Stickleback.Integrative and comparative biology · 2026Article
- Spatiotemporal Patterns of Gene Expression Associated With Mating Stimuli in the Brain of Female Guppies.Genes, brain, and behavior · 2025Article
- Temporal dynamics and adaptiveness of thermal phenotypic plasticity in a ciliate.Evolution letters · 2025Article
- A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.Science advances · 2025Article
- Repeated behavioural evolution is associated with convergence of gene expression in cavity-nesting songbirds.Nature ecology & evolution · 2025Article
- Brain transcriptomics of a social challenge and maternal aggression in incubating female tree swallows.Hormones and behavior · 2025Article
- QTL-Based Evidence of Population Genetic Divergence in Male Territorial Aggressiveness of the Japanese Freshwater Threespine Stickleback.Ecology and evolution · 2025Article
- Neural mechanisms of mutualistic fish cleaning behaviour: a study in the wild.Biology letters · 2024Article
- Transcriptomic changes in the posterior pallium of male zebra finches associated with social niche conformance.BMC genomics · 2024Article
- Individual variation in preference behavior in sailfin fish refines the neurotranscriptomic pathway for mate preference.Ecology and evolution · 2023Article
- Alternative splicing plays key roles in response to stress across different stages of fighting in the fish Betta splendens.BMC genomics · 2022Article
- Back to the basics? Transcriptomics offers integrative insights into the role of space, time and the environment for gene expression and behaviour.Biology letters · 2021Article
- Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps.PLoS genetics · 2021Article
- Threespine Stickleback: A Model System For Evolutionary Genomics.Annual review of genomics and human genetics · 2021Review
- Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Minimally invasive brain injections for viral-mediated transgenesis: New tools for behavioral genetics in sticklebacks.PloS one · 2021Article
- Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.eLife · 2020Article
- Biological embedding of experience: A primer on epigenetics.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Animals exhibit dramatic immediate behavioral plasticity in response to social interactions, and brief social interactions can shape the future social landscape. However, the molecular mechanisms contributing to behavioral plasticity are unclear. Here, we show that the genome dynamically responds to social interactions with multiple waves of transcription associated with distinct molecular functions in the brain of male threespined sticklebacks, a species famous for its behavioral repertoire and evolution. Some biological functions (e.g., hormone activity) peaked soon after a brief territorial challenge and then declined, while others (e.g., immune response) peaked hours afterwards. We identify transcription factors that are predicted to coordinate waves of transcription associated with different components of behavioral plasticity. Next, using H3K27Ac as a marker of chromatin accessibility, we show that a brief territorial intrusion was sufficient to cause rapid and dramatic changes in the epigenome. Finally, we integrate the time course brain gene expression data with a transcriptional regulatory network, and link gene expression to changes in chromatin accessibility. This study reveals rapid and dramatic epigenomic plasticity in response to a brief, highly consequential social interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.